Diffuse large B cell lymphoma (DLBCL) in pakistan: An emerging epidemic?

Muhammad Bilal Abid, Faria Nasim, Kashif Anwar, Shahid Pervez

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30 Citations (Scopus)


There has been a recent concern among oncological clinicians and pathologists of our region regarding the disproportionate increase in the number of patients presenting with diffuse large B cell lymphoma (DLBCL). This prompted us to conduct a thorough, hospital-based epidemiological study in a major referral center of Pakistan. A total of 780 specimens were collected over last half decade from cases classified as adult Non Hodgkin's lymphoma (NHL). Out of these 780, 596 (76.4 %)were diagnosed as DLBCLs. The gender ratio was 2.3: 1 (M: F) and the median age was 47.2 years, with an age range of 15-85years. Nodal-NHLs constituted 42.2 % of all adult NHLs, with the cervical lymph nodes as the most frequent nodal site of presentation. The most frequent extranodal site was the gastro-intestinal tract (GIT), followed by the head and neck. In conclusion, we document an astonishingly high number of DLBCL amounting to an emerging epidemic in Pakistan, with a consideration of probable etiopathogenetic factors.

Original languageEnglish
Pages (from-to)531-534
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Issue number4
Publication statusPublished - 2005


  • NHL
  • Pakistani adults


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