Diffusion Tensor Imaging in the Diagnosis of Primary Lateral Sclerosis

Aziz M. Uluǧ, Thomas Grünewald, Michael T. Lin, Ayeesha K. Kamal, Christopher G. Filippi, Robert D. Zimmerman, M. Flint Beal

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47 Citations (Scopus)

Abstract

Purpose: To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS). Materials and Methods: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging. Results: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness. Conclusion: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2004
Externally publishedYes

Keywords

  • ALS
  • Babinski sign
  • Diffusion tensor imaging
  • MRI
  • Primary lateral sclerosis
  • Upper motor neuron disease

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