Drug resistance of Mycobacterium tuberculosis in Karachi, Pakistan

Javaid Khan, Najmul Islam, Nadya Ajanee, Wasim Jafri

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


We determined the primary and secondary resistance of isolates of M. tuberculosis to the standard anti-tuberculous drugs in Karachi (Pakistan). Primary resistance to one or more anti-tuberculous drugs was found in 17% of 123 isolates of M. tuberculosis (obtained from patients with no history of previous treatment for tuberculosis). Secondary resistance was found in 36% of 33 isolates (obtained from individuals who had received anti-tuberculous treatment in the past). The drug to which organisms were most commonly resistant was isoniazid (11% primary resistance, 30% secondary resistance). Fifteen per cent of isolates obtained from previously-studied patients showed secondary resistance to rifampicin. We discuss the importance of these findings for tuberculosis treatment and control.

Original languageEnglish
Pages (from-to)13-14
Number of pages2
JournalTropical Doctor
Issue number1
Publication statusPublished - Jan 1993


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