Dubin-Johnson syndrome

Aziz-un-Nisa, Zubair Ahmad

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A young man presented with recurrent episodes of mild jaundice. Apart from conjugated hyperbilirubinemia, other liver function tests were always normal. Clinical suspicion of Dubin-Johnson syndrome was raised. Liver biopsy showed diffuse deposition of coarse granular dark brown pigment in hepatocytes. Dubin-Johnson syndrome is a benign condition, which results from a hereditary defect in biliary secretioh of bilirubin pigments, and manifests as recurrent jaundice with conjugated hyperbilirubinemia. The defect is due to the absence of the canalicular protein MRP2 located on chromosomes 10q 24, which is responsible for the transport of biliary glucuronides and related organic anions into bile. No treatment is necessary and patients have a normal life expectancy.

Original languageEnglish
Pages (from-to)188-189
Number of pages2
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Issue number3
Publication statusPublished - Mar 2008


  • Brown pigment
  • Conjugated hyperbilirubinemia
  • Dubin-Johnson syndrome
  • Liver biopsy


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