Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected

Julia Sawatzky; Andrea L. Conroy; Jeanne Brochon; Fatima Kakkar; Jason Brophy; Sophie Namasopo; Robert O. Opoka; Michael T. Hawkes

doi:10.1097/QAD.0000000000004424

Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected

Julia Sawatzky
, Andrea L. Conroy
, Jeanne Brochon
, Fatima Kakkar
, Jason Brophy
, Sophie Namasopo
, Robert O. Opoka
, Michael T. Hawkes

Research output: Contribution to journal › Article › peer-review

Abstract

HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023–0.19] among infants with LBW and 0.018 (IQR 0.010–0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.

Original language	English (US)
Pages (from-to)	696-699
Number of pages	4
Journal	AIDS
Volume	40
Issue number	5
DOIs	https://doi.org/10.1097/QAD.0000000000004424
Publication status	Published - May 2026
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1097/QAD.0000000000004424

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title = "Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected",

abstract = "HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023–0.19] among infants with LBW and 0.018 (IQR 0.010–0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.",

author = "Julia Sawatzky and Conroy, \{Andrea L.\} and Jeanne Brochon and Fatima Kakkar and Jason Brophy and Sophie Namasopo and Opoka, \{Robert O.\} and Hawkes, \{Michael T.\}",

year = "2026",

month = may,

doi = "10.1097/QAD.0000000000004424",

language = "English (US)",

volume = "40",

pages = "696--699",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

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}

TY - JOUR

T1 - Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected

AU - Sawatzky, Julia

AU - Conroy, Andrea L.

AU - Brochon, Jeanne

AU - Kakkar, Fatima

AU - Brophy, Jason

AU - Namasopo, Sophie

AU - Opoka, Robert O.

AU - Hawkes, Michael T.

PY - 2026/5

Y1 - 2026/5

N2 - HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023–0.19] among infants with LBW and 0.018 (IQR 0.010–0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.

AB - HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023–0.19] among infants with LBW and 0.018 (IQR 0.010–0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.

UR - https://www.scopus.com/pages/publications/105034367171

U2 - 10.1097/QAD.0000000000004424

DO - 10.1097/QAD.0000000000004424

M3 - Article

C2 - 41891219

AN - SCOPUS:105034367171

SN - 0269-9370

VL - 40

SP - 696

EP - 699

JO - AIDS

JF - AIDS

IS - 5

ER -

Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected

Abstract

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