TY - JOUR
T1 - Early Stage Breast Cancer
T2 - Does Histologic Subtype (Ductal vs. Lobular) Impact 5 Year Overall Survival?
AU - Mubarak, Fatima
AU - Kowkabany, Gabrielle
AU - Popp, Reed
AU - Bansal, Shivam
AU - Ahmed, Syeda Hoorulain
AU - Sharan, Seema
AU - Sukniam, Kulkaew B.
AU - Raikot, Swathi R.
AU - Jimenez, Paola Berrios
AU - Popp, Kyle
AU - Manaise, Harsheen K.
AU - Gabriel, Emmanuel
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/4
Y1 - 2024/4
N2 - Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) (p = 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77–0.93, p = 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients.
AB - Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) (p = 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77–0.93, p = 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients.
KW - breast cancer
KW - histology
KW - overall survival
UR - http://www.scopus.com/inward/record.url?scp=85191377520&partnerID=8YFLogxK
U2 - 10.3390/cancers16081509
DO - 10.3390/cancers16081509
M3 - Article
AN - SCOPUS:85191377520
SN - 2072-6694
VL - 16
JO - Cancers
JF - Cancers
IS - 8
M1 - 1509
ER -
