Abstract
Objective: To determine the chronic stress induced decline in plasma Neuropeptide Y (NPY) level and protective effects of Alpha Tocopherol (AT) on maintenance of Neuropeptide Y level. Study Design: Quasi-experimental study. Place and Duration of Study: The study settings were Al-Nafees Medical College and animal center of National Institute of Health Islamabad (NIH). Duration of research was one year from May 2015 to May 2016. Methodology: After taking approval of institutional review board 45 male Sprague Dawley rats with inclusion criteria were chosen and allocated to three groups comprised of n=15. Group I was control, group II restraint stress and group III (restraint stress with supplementation of alpha-tocopherol). After 28 days of restraining stress induction plasma Neuropeptide Y level was determined by sandwich Enzyme Linked Immunosorbent Assay (ELISA). Results: There was a statistically significant decline (p<0.05) in plasma Neuropeptide Y levels in restraint group as compared to control group and with alpha-tocopherol supplementation group. Conclusion: Chronic restraint stress induction led to decline in Neuropeptide Y levels and alpha-tocopherol prevented fall in Neuropeptide Y levels.
| Original language | English (UK) |
|---|---|
| Pages (from-to) | 776-780 |
| Number of pages | 5 |
| Journal | Pakistan Armed Forces Medical Journal |
| Volume | 70 |
| Issue number | 3 |
| Publication status | Published - Jun 2020 |
| Externally published | Yes |
Keywords
- Alpha-Tocopherol
- Neuropeptide Y
- Sprague dawley rats
