Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents

Shagufta Khan, Ghulam Abbas, Fahad Shabbir Ahmed, Atta-Ur-Rahman, Ahsana Dar

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PEA-induced stereotypes (20%). Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels (probably via monoamine oxidase A inhibition) and does not induce cheese effect.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalPakistan Journal of Pharmaceutical Sciences
Volume27
Issue number2
Publication statusPublished - Mar 2014

Keywords

  • Areca catechu nut
  • Cheese effect
  • Dichloromethane fraction
  • Dopamine
  • Serotonin

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