TY - JOUR
T1 - Effect of high-efficiency particulate air filter on children with asthma
T2 - A systematic review protocol of RCTs
AU - Mansoor, Javeria
AU - Zia Ul Haq, Muhammad
AU - Ahsan, Zeeshan
AU - Bilal, Muhammad
AU - Fatima, Syeda Sadia
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024.
PY - 2024/12/15
Y1 - 2024/12/15
N2 - Introduction Asthma has been classified as a major non-communicable disease by the WHO. With the worsening air quality index worldwide, the burden of asthma has increased specifically in children. The focus of the management strategy of asthma has shifted from traditional pharmacological treatments towards non-pharmacological preventive and control therapy in recent decades. The use of high-efficiency particulate air (HEPA) filters is one of the methods to achieve that, despite extensive research, the efficacy of HEPA filters in this context of effectiveness and usage guidelines remains unclear. Our study aims to examine the effect of HEPA filters in (1) reducing clinical visits or hospital admissions or the number of exacerbation events, (2) reducing asthma symptoms, (3) increasing asthma symptom-free days, (4) reducing indoor particulate matter 2.5 levels for children with asthma aged 5-17 years and (5) improving quality of life. Methods We will conduct a systematic review using MEDLINE, Google Scholar and Scopus as databases, article selection is planned to be restricted to randomised controlled trials only (2002-2025). We are following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines developed specifically for the protocol(s). Two reviewers will screen the studies independently and assess study quality using the Cochrane Risk of Bias Tool for Randomised Trials, V.2. The results of outcome measure(s) will be summarised in tables. If the studies are sufficient, we will also perform a quantitative analysis by creating forest plots and subgroup analysis will be performed if required. Lastly, publication bias will be assessed using a funnel plot and Egger's test and reported accordingly. Ethics and dissemination We will conduct a systematic review, therefore there is no need for a formal ethical review. After successful completion, our results will be published in a peer-reviewed journal. PROSPERO registration number CR42024494949.
AB - Introduction Asthma has been classified as a major non-communicable disease by the WHO. With the worsening air quality index worldwide, the burden of asthma has increased specifically in children. The focus of the management strategy of asthma has shifted from traditional pharmacological treatments towards non-pharmacological preventive and control therapy in recent decades. The use of high-efficiency particulate air (HEPA) filters is one of the methods to achieve that, despite extensive research, the efficacy of HEPA filters in this context of effectiveness and usage guidelines remains unclear. Our study aims to examine the effect of HEPA filters in (1) reducing clinical visits or hospital admissions or the number of exacerbation events, (2) reducing asthma symptoms, (3) increasing asthma symptom-free days, (4) reducing indoor particulate matter 2.5 levels for children with asthma aged 5-17 years and (5) improving quality of life. Methods We will conduct a systematic review using MEDLINE, Google Scholar and Scopus as databases, article selection is planned to be restricted to randomised controlled trials only (2002-2025). We are following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines developed specifically for the protocol(s). Two reviewers will screen the studies independently and assess study quality using the Cochrane Risk of Bias Tool for Randomised Trials, V.2. The results of outcome measure(s) will be summarised in tables. If the studies are sufficient, we will also perform a quantitative analysis by creating forest plots and subgroup analysis will be performed if required. Lastly, publication bias will be assessed using a funnel plot and Egger's test and reported accordingly. Ethics and dissemination We will conduct a systematic review, therefore there is no need for a formal ethical review. After successful completion, our results will be published in a peer-reviewed journal. PROSPERO registration number CR42024494949.
KW - Asthma
KW - Child
KW - Systematic Review
UR - https://www.scopus.com/pages/publications/85212888652
U2 - 10.1136/bmjopen-2024-087493
DO - 10.1136/bmjopen-2024-087493
M3 - Review article
C2 - 39675828
AN - SCOPUS:85212888652
SN - 2044-6055
VL - 14
JO - BMJ Open
JF - BMJ Open
IS - 12
M1 - e087493
ER -
