Effect of low dose oral pill on haemostatic parameters in a set of Pakistani population

Nasir Ali Afsar; Qamaruddin Barakzai; Salman Naseem Adil

Effect of low dose oral pill on haemostatic parameters in a set of Pakistani population

Nasir Ali Afsar
, Qamaruddin Barakzai
, Salman Naseem Adil

Department of Pathology and Laboratory Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Objective: To observe the adverse effects of low dose combination contraceptive pills on blood coagulation in a set of local population. Methods: Between December 2002 to December 2003 a comparative cross-sectional study was conducted at the Department of Pharmacology, Ziauddin Medical University, Karachi and Aga Khan University Hospital, Karachi. Fifty women of reproductive age were divided in two equal groups; one being the users of combination oral contraceptive pills (ethinyl estradiol and levonorgestrel) and the other being matching controls not taking any hormonal contraceptives. We studied, CBC, PT and INR, APTT, BT and platelet aggregation against ADP, collagen, epinephrine and ristocetin. Results: PT, INR, and platelet aggregation response to ADP, collagen, epinephrine, and ristocetin were not significantly different among the groups. However, APTT was shortened in users of contraceptives (p = 0.003). Conclusion: The referred oral contraceptive is associated with enhanced activity of intrinsic pathway of secondary haemostasis.

Original language	English (UK)
Pages (from-to)	229-233
Number of pages	5
Journal	Journal of the Pakistan Medical Association
Volume	58
Issue number	5
Publication status	Published - May 2008

Cite this

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title = "Effect of low dose oral pill on haemostatic parameters in a set of Pakistani population",

abstract = "Objective: To observe the adverse effects of low dose combination contraceptive pills on blood coagulation in a set of local population. Methods: Between December 2002 to December 2003 a comparative cross-sectional study was conducted at the Department of Pharmacology, Ziauddin Medical University, Karachi and Aga Khan University Hospital, Karachi. Fifty women of reproductive age were divided in two equal groups; one being the users of combination oral contraceptive pills (ethinyl estradiol and levonorgestrel) and the other being matching controls not taking any hormonal contraceptives. We studied, CBC, PT and INR, APTT, BT and platelet aggregation against ADP, collagen, epinephrine and ristocetin. Results: PT, INR, and platelet aggregation response to ADP, collagen, epinephrine, and ristocetin were not significantly different among the groups. However, APTT was shortened in users of contraceptives (p = 0.003). Conclusion: The referred oral contraceptive is associated with enhanced activity of intrinsic pathway of secondary haemostasis.",

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AU - Afsar, Nasir Ali

AU - Barakzai, Qamaruddin

AU - Adil, Salman Naseem

PY - 2008/5

Y1 - 2008/5

N2 - Objective: To observe the adverse effects of low dose combination contraceptive pills on blood coagulation in a set of local population. Methods: Between December 2002 to December 2003 a comparative cross-sectional study was conducted at the Department of Pharmacology, Ziauddin Medical University, Karachi and Aga Khan University Hospital, Karachi. Fifty women of reproductive age were divided in two equal groups; one being the users of combination oral contraceptive pills (ethinyl estradiol and levonorgestrel) and the other being matching controls not taking any hormonal contraceptives. We studied, CBC, PT and INR, APTT, BT and platelet aggregation against ADP, collagen, epinephrine and ristocetin. Results: PT, INR, and platelet aggregation response to ADP, collagen, epinephrine, and ristocetin were not significantly different among the groups. However, APTT was shortened in users of contraceptives (p = 0.003). Conclusion: The referred oral contraceptive is associated with enhanced activity of intrinsic pathway of secondary haemostasis.

AB - Objective: To observe the adverse effects of low dose combination contraceptive pills on blood coagulation in a set of local population. Methods: Between December 2002 to December 2003 a comparative cross-sectional study was conducted at the Department of Pharmacology, Ziauddin Medical University, Karachi and Aga Khan University Hospital, Karachi. Fifty women of reproductive age were divided in two equal groups; one being the users of combination oral contraceptive pills (ethinyl estradiol and levonorgestrel) and the other being matching controls not taking any hormonal contraceptives. We studied, CBC, PT and INR, APTT, BT and platelet aggregation against ADP, collagen, epinephrine and ristocetin. Results: PT, INR, and platelet aggregation response to ADP, collagen, epinephrine, and ristocetin were not significantly different among the groups. However, APTT was shortened in users of contraceptives (p = 0.003). Conclusion: The referred oral contraceptive is associated with enhanced activity of intrinsic pathway of secondary haemostasis.

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JO - Journal of the Pakistan Medical Association

JF - Journal of the Pakistan Medical Association

IS - 5

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Effect of low dose oral pill on haemostatic parameters in a set of Pakistani population

Abstract

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