Effects of acute restraint stress on endogenous adrenomedullin levels

S. Khan; D. Michaud; T. W. Moody; H. Anisman; Z. Merali

doi:10.1097/00001756-199909090-00024

Effects of acute restraint stress on endogenous adrenomedullin levels

S. Khan, D. Michaud, T. W. Moody, H. Anisman, Z. Merali

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

ADRENOMEDULLIN (ADM) is a 52 amino acid peptide, with a potent hypotensive/vasodilatory action. Levels of ADM are significantly elevated in patients with hypertension, and it has been postulated that such stressor- related increases may serve a regulatory or protective function. The current study assessed the effects of acute restraint stress on ADM levels in regions of the brain, plasma and peripheral tissue including heart, lung and the adrenal glands of rats. This stressor, known to stimulate sympathetic activity as well as the hypothalamic-pituitary adrenal (HPA) axis, produced a significant increase in ADM levels in the pituitary gland, plasma and adrenal glands, all of which are key components of the HPA axis. The results suggest a regulatory and/or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors.

Original language	English
Pages (from-to)	2829-2833
Number of pages	5
Journal	NeuroReport
Volume	10
Issue number	13
DOIs	https://doi.org/10.1097/00001756-199909090-00024
Publication status	Published - 9 Sept 1999
Externally published	Yes

Keywords

ACTH
Adrenomedullin
HPA axis
Homeostasis
Restraint stress

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10.1097/00001756-199909090-00024

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title = "Effects of acute restraint stress on endogenous adrenomedullin levels",

abstract = "ADRENOMEDULLIN (ADM) is a 52 amino acid peptide, with a potent hypotensive/vasodilatory action. Levels of ADM are significantly elevated in patients with hypertension, and it has been postulated that such stressor- related increases may serve a regulatory or protective function. The current study assessed the effects of acute restraint stress on ADM levels in regions of the brain, plasma and peripheral tissue including heart, lung and the adrenal glands of rats. This stressor, known to stimulate sympathetic activity as well as the hypothalamic-pituitary adrenal (HPA) axis, produced a significant increase in ADM levels in the pituitary gland, plasma and adrenal glands, all of which are key components of the HPA axis. The results suggest a regulatory and/or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors.",

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AU - Michaud, D.

AU - Moody, T. W.

AU - Anisman, H.

AU - Merali, Z.

PY - 1999/9/9

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N2 - ADRENOMEDULLIN (ADM) is a 52 amino acid peptide, with a potent hypotensive/vasodilatory action. Levels of ADM are significantly elevated in patients with hypertension, and it has been postulated that such stressor- related increases may serve a regulatory or protective function. The current study assessed the effects of acute restraint stress on ADM levels in regions of the brain, plasma and peripheral tissue including heart, lung and the adrenal glands of rats. This stressor, known to stimulate sympathetic activity as well as the hypothalamic-pituitary adrenal (HPA) axis, produced a significant increase in ADM levels in the pituitary gland, plasma and adrenal glands, all of which are key components of the HPA axis. The results suggest a regulatory and/or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors.

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KW - HPA axis

KW - Homeostasis

KW - Restraint stress

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Effects of acute restraint stress on endogenous adrenomedullin levels

Abstract

Keywords

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