Effects of anthropometric and metabolic parameters on transaminase levels and liver stiffness in patients with non-alcohol fatty liver disease

Shoukat Ali Samejo, Zaigham Abbas, Muhammad Asim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We aimed to investigate 214 patients further with non-alcoholic fatty liver disease (NAFLD) as judged by transient elastography. A body mass index of ≥25 was seen in 172 (80%) of the patients. F2–F4 fibrosis, as depicted by elastography, was present in 114 (53.2%). A Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) of ≥2 was seen in 178 (83.2%). Alanine aminotransferase was elevated in 116 (54%) and aspartate aminotransferase in 88 (41.1%). Liver steatosis was significantly associated with increasing alanine aminotransferase, insulin, HOMA-IR and cholesterol levels. Regression analysis showed cholesterol as a factor independently associated with the degree of liver steatosis. The independent variable related to increasing liver elasticity was steatosis. In conclusion, a significant number of our patients with NAFLD had steatohepatitis and F2–F4 fibrosis.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalTropical Doctor
Volume51
Issue number2
DOIs
Publication statusPublished - Apr 2021
Externally publishedYes

Keywords

  • Non-alcoholic fatty liver disease
  • cirrhosis
  • liver fibrosis

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