Effects of dietary copper exposure on accumulation, growth, and hematological parameters in Cyprinus carpio

A. S. Al-Akel, H. F.Alkahem Al-Balawi, F. Al-Misned, Shahid Mahboobab, Z. Ahmad, E. M. Suliman

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The influence of dietary copper (Cu) exposure on accumulation, growth, and hematological parameters was investigated in Cyprinus carpio after sub-chronic ingestion of 0, 250, 500, 750 or 1000mg kg-1 for 60 days. The profile of Cu accumulation among tissues in C. carpio was dependent on the exposure period and Cu concentration. Liver of C. carpio was the predominant storage tissue and the order of Cu accumulation in tissues was liver>intestine> gill>kidney>muscle. Cu concentration at 4125mg kg-1 reduced growth rate, and was inversely related to growth. The RNA:DNA ratios were not affected by exposure and there was no correlation between growth rate and RNA:DNA ratio in liver and muscle. There were no significant effects of exposure on blood parameters except for magnesium. Cu exposure time and dose increased the serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) activity levels.

Original languageEnglish
Pages (from-to)1865-1878
Number of pages14
JournalToxicological and Environmental Chemistry
Volume92
Issue number10
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Cprinus carpio
  • Dietary copper
  • Growth
  • Hematological parameters
  • Rna:dna ratio

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