Effects of parenteral vanadium administration on pulmonary metabolism of rats

Sam Kacew; Mano R. Parulekar; Zulfiquar Merali

doi:10.1016/0378-4274(82)90115-1

Effects of parenteral vanadium administration on pulmonary metabolism of rats

Sam Kacew, Mano R. Parulekar, Zulfiquar Merali

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Daily, intraperitoneal administration of either vanadium pentoxide (VP) or sodium vanadate (NaV) at a dose of 1 mg/kg for 14 days produced no marked change in pulmonary protein, glycogen and phospholipid (PL) levels of adult male rats. Increasing the VP dose to 4 mg/kg decreased lung PL content, while an equivalent NaV dose elevated tissue glycogen. Treatment with either dosage of NaV elevated the activities of pulmonary 6-phosphogluconate dehydrogenase (6PGDH), pyruvate kinase (PK) and glutathione peroxidase (GP), and the higher dose increased lactate dehydrogenase (LDH) and glutathione reductase (GR). The 1 mg/kg VP produced a significant rise in glucose-6-phosphate dehydrogenase (G6PDH) and 6PGDH, while the higher VP dose in general failed to alter enzymic activity. Our data suggest that similar to intratracheal instillation, parenteral administration of vanadium exerts an effect on lung metabolism of rats.

Original language	English
Pages (from-to)	119-124
Number of pages	6
Journal	Toxicology Letters
Volume	11
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-4274(82)90115-1
Publication status	Published - Apr 1982
Externally published	Yes

Access to Document

10.1016/0378-4274(82)90115-1

Cite this

@article{95dc2c8437b74d5ea76de5b3f47f6f4b,

title = "Effects of parenteral vanadium administration on pulmonary metabolism of rats",

abstract = "Daily, intraperitoneal administration of either vanadium pentoxide (VP) or sodium vanadate (NaV) at a dose of 1 mg/kg for 14 days produced no marked change in pulmonary protein, glycogen and phospholipid (PL) levels of adult male rats. Increasing the VP dose to 4 mg/kg decreased lung PL content, while an equivalent NaV dose elevated tissue glycogen. Treatment with either dosage of NaV elevated the activities of pulmonary 6-phosphogluconate dehydrogenase (6PGDH), pyruvate kinase (PK) and glutathione peroxidase (GP), and the higher dose increased lactate dehydrogenase (LDH) and glutathione reductase (GR). The 1 mg/kg VP produced a significant rise in glucose-6-phosphate dehydrogenase (G6PDH) and 6PGDH, while the higher VP dose in general failed to alter enzymic activity. Our data suggest that similar to intratracheal instillation, parenteral administration of vanadium exerts an effect on lung metabolism of rats.",

author = "Sam Kacew and Parulekar, {Mano R.} and Zulfiquar Merali",

note = "Funding Information: This work was supported by grants from the Medical ResearchC ouncil of Canada. The authors are indebted to Miss S. McConnell for her technical assistance.",

year = "1982",

month = apr,

doi = "10.1016/0378-4274(82)90115-1",

language = "English",

volume = "11",

pages = "119--124",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "1-2",

}

TY - JOUR

T1 - Effects of parenteral vanadium administration on pulmonary metabolism of rats

AU - Kacew, Sam

AU - Parulekar, Mano R.

AU - Merali, Zulfiquar

N1 - Funding Information: This work was supported by grants from the Medical ResearchC ouncil of Canada. The authors are indebted to Miss S. McConnell for her technical assistance.

PY - 1982/4

Y1 - 1982/4

N2 - Daily, intraperitoneal administration of either vanadium pentoxide (VP) or sodium vanadate (NaV) at a dose of 1 mg/kg for 14 days produced no marked change in pulmonary protein, glycogen and phospholipid (PL) levels of adult male rats. Increasing the VP dose to 4 mg/kg decreased lung PL content, while an equivalent NaV dose elevated tissue glycogen. Treatment with either dosage of NaV elevated the activities of pulmonary 6-phosphogluconate dehydrogenase (6PGDH), pyruvate kinase (PK) and glutathione peroxidase (GP), and the higher dose increased lactate dehydrogenase (LDH) and glutathione reductase (GR). The 1 mg/kg VP produced a significant rise in glucose-6-phosphate dehydrogenase (G6PDH) and 6PGDH, while the higher VP dose in general failed to alter enzymic activity. Our data suggest that similar to intratracheal instillation, parenteral administration of vanadium exerts an effect on lung metabolism of rats.

AB - Daily, intraperitoneal administration of either vanadium pentoxide (VP) or sodium vanadate (NaV) at a dose of 1 mg/kg for 14 days produced no marked change in pulmonary protein, glycogen and phospholipid (PL) levels of adult male rats. Increasing the VP dose to 4 mg/kg decreased lung PL content, while an equivalent NaV dose elevated tissue glycogen. Treatment with either dosage of NaV elevated the activities of pulmonary 6-phosphogluconate dehydrogenase (6PGDH), pyruvate kinase (PK) and glutathione peroxidase (GP), and the higher dose increased lactate dehydrogenase (LDH) and glutathione reductase (GR). The 1 mg/kg VP produced a significant rise in glucose-6-phosphate dehydrogenase (G6PDH) and 6PGDH, while the higher VP dose in general failed to alter enzymic activity. Our data suggest that similar to intratracheal instillation, parenteral administration of vanadium exerts an effect on lung metabolism of rats.

UR - http://www.scopus.com/inward/record.url?scp=0020034499&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(82)90115-1

DO - 10.1016/0378-4274(82)90115-1

M3 - Article

C2 - 7090002

AN - SCOPUS:0020034499

SN - 0378-4274

VL - 11

SP - 119

EP - 124

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1-2

ER -

Effects of parenteral vanadium administration on pulmonary metabolism of rats

Abstract

Access to Document

Other files and links

Fingerprint

Cite this