Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Tuberculosis (TB) remains an important global public health issue with an approximate prevalence of 10 million people with TB worldwide in 2015. Since antibiotic treatment is one of the foremost tools for TB control, knowledge of Mycobacterium tuberculosis (MTB) drug resistance is an important component for disease control. Although gene mutations in specific loci of the MTB genomes are reported as the primary basis for drug resistance, additional mechanisms conferring resistance to MTB are thought to exist. Efflux is a ubiquitous mechanism responsible for innate and acquired drug resistance in prokaryotic and eukaryotic cells. MTB presents a large number of putative drug efflux pumps compared to its genome size. Bioinformatics-based evidence has shown an association between drug efflux and innate or acquired resistance in MTB. This review describes the recent understanding of drug efflux in MTB.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalIndian Journal of Tuberculosis
Volume66
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • ABC transporters
  • Drug efflux pumps
  • Drug resistance
  • MFS transporters
  • Mycobacterium tuberculosis

Fingerprint

Dive into the research topics of 'Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis'. Together they form a unique fingerprint.

Cite this