Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis

Akbar Kanji; Rumina Hasan; Zahra Hasan

doi:10.1016/j.ijtb.2018.07.008

Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis

Akbar Kanji, Rumina Hasan, Zahra Hasan

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Tuberculosis (TB) remains an important global public health issue with an approximate prevalence of 10 million people with TB worldwide in 2015. Since antibiotic treatment is one of the foremost tools for TB control, knowledge of Mycobacterium tuberculosis (MTB) drug resistance is an important component for disease control. Although gene mutations in specific loci of the MTB genomes are reported as the primary basis for drug resistance, additional mechanisms conferring resistance to MTB are thought to exist. Efflux is a ubiquitous mechanism responsible for innate and acquired drug resistance in prokaryotic and eukaryotic cells. MTB presents a large number of putative drug efflux pumps compared to its genome size. Bioinformatics-based evidence has shown an association between drug efflux and innate or acquired resistance in MTB. This review describes the recent understanding of drug efflux in MTB.

Original language	English
Pages (from-to)	20-25
Number of pages	6
Journal	Indian Journal of Tuberculosis
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/j.ijtb.2018.07.008
Publication status	Published - Jan 2019

Keywords

ABC transporters
Drug efflux pumps
Drug resistance
MFS transporters
Mycobacterium tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijtb.2018.07.008

Cite this

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abstract = "Tuberculosis (TB) remains an important global public health issue with an approximate prevalence of 10 million people with TB worldwide in 2015. Since antibiotic treatment is one of the foremost tools for TB control, knowledge of Mycobacterium tuberculosis (MTB) drug resistance is an important component for disease control. Although gene mutations in specific loci of the MTB genomes are reported as the primary basis for drug resistance, additional mechanisms conferring resistance to MTB are thought to exist. Efflux is a ubiquitous mechanism responsible for innate and acquired drug resistance in prokaryotic and eukaryotic cells. MTB presents a large number of putative drug efflux pumps compared to its genome size. Bioinformatics-based evidence has shown an association between drug efflux and innate or acquired resistance in MTB. This review describes the recent understanding of drug efflux in MTB.",

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AU - Kanji, Akbar

AU - Hasan, Rumina

AU - Hasan, Zahra

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AB - Tuberculosis (TB) remains an important global public health issue with an approximate prevalence of 10 million people with TB worldwide in 2015. Since antibiotic treatment is one of the foremost tools for TB control, knowledge of Mycobacterium tuberculosis (MTB) drug resistance is an important component for disease control. Although gene mutations in specific loci of the MTB genomes are reported as the primary basis for drug resistance, additional mechanisms conferring resistance to MTB are thought to exist. Efflux is a ubiquitous mechanism responsible for innate and acquired drug resistance in prokaryotic and eukaryotic cells. MTB presents a large number of putative drug efflux pumps compared to its genome size. Bioinformatics-based evidence has shown an association between drug efflux and innate or acquired resistance in MTB. This review describes the recent understanding of drug efflux in MTB.

KW - ABC transporters

KW - Drug efflux pumps

KW - Drug resistance

KW - MFS transporters

KW - Mycobacterium tuberculosis

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Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis

Abstract

Keywords

UN SDGs

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