Efforts in diagnosing early leprosy using serological techniques

O. M. Parkash; M. K. Beuria; B. K. Girdhar; K. Katoch; U. Sengupta

doi:10.1007/BF02703623

Efforts in diagnosing early leprosy using serological techniques

O. M. Parkash
, M. K. Beuria
, B. K. Girdhar
, K. Katoch
, U. Sengupta

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Skin scrapings obtained from the lesions of leprosy patients of all types showed 96% positivity to the serum antibody competition test using monoclonal antibody (MLO4) to 35 kDa antigen of Mycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from lepromatous patients were noted to release IgG antibodies to M. leprae with a peak antibody response at 48 h. The significance of this local antibody response to M. leprae in skin has been discussed for its possible use in diagnosing early leprosy.

Original language	English (UK)
Pages (from-to)	111-116
Number of pages	6
Journal	Journal of Biosciences
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/BF02703623
Publication status	Published - Jan 1997
Externally published	Yes

Keywords

Leprosy
Mycobacterium leprae 35 kDa antigen
Skin biopsies
Skin scrapings

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10.1007/BF02703623

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title = "Efforts in diagnosing early leprosy using serological techniques",

abstract = "Skin scrapings obtained from the lesions of leprosy patients of all types showed 96\% positivity to the serum antibody competition test using monoclonal antibody (MLO4) to 35 kDa antigen of Mycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from lepromatous patients were noted to release IgG antibodies to M. leprae with a peak antibody response at 48 h. The significance of this local antibody response to M. leprae in skin has been discussed for its possible use in diagnosing early leprosy.",

keywords = "Leprosy, Mycobacterium leprae 35 kDa antigen, Skin biopsies, Skin scrapings",

author = "Parkash, \{O. M.\} and Beuria, \{M. K.\} and Girdhar, \{B. K.\} and K. Katoch and U. Sengupta",

year = "1997",

month = jan,

doi = "10.1007/BF02703623",

language = "English (UK)",

volume = "22",

pages = "111--116",

journal = "Journal of Biosciences",

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T1 - Efforts in diagnosing early leprosy using serological techniques

AU - Parkash, O. M.

AU - Beuria, M. K.

AU - Girdhar, B. K.

AU - Katoch, K.

AU - Sengupta, U.

PY - 1997/1

Y1 - 1997/1

N2 - Skin scrapings obtained from the lesions of leprosy patients of all types showed 96% positivity to the serum antibody competition test using monoclonal antibody (MLO4) to 35 kDa antigen of Mycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from lepromatous patients were noted to release IgG antibodies to M. leprae with a peak antibody response at 48 h. The significance of this local antibody response to M. leprae in skin has been discussed for its possible use in diagnosing early leprosy.

AB - Skin scrapings obtained from the lesions of leprosy patients of all types showed 96% positivity to the serum antibody competition test using monoclonal antibody (MLO4) to 35 kDa antigen of Mycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from lepromatous patients were noted to release IgG antibodies to M. leprae with a peak antibody response at 48 h. The significance of this local antibody response to M. leprae in skin has been discussed for its possible use in diagnosing early leprosy.

KW - Leprosy

KW - Mycobacterium leprae 35 kDa antigen

KW - Skin biopsies

KW - Skin scrapings

UR - https://www.scopus.com/pages/publications/0030763948

U2 - 10.1007/BF02703623

DO - 10.1007/BF02703623

M3 - Article

AN - SCOPUS:0030763948

SN - 0250-5991

VL - 22

SP - 111

EP - 116

JO - Journal of Biosciences

JF - Journal of Biosciences

IS - 1

ER -

Efforts in diagnosing early leprosy using serological techniques

Abstract

Keywords

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