Eliminating Infections in the ICU: CLABSI

Asad Latif, Muhammad Sohail Halim, Peter J. Pronovost

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


Central line-associated bloodstream infections (CLABSI) are one of the leading causes of death in the USA and around the world. As a preventable healthcare-associated infection, they are associated with significant morbidity and excess costs to the healthcare system. Effective and long-term CLABSI prevention requires a multifaceted approach, involving evidence-based best practices coupled with effective implementation strategies. Currently recommended practices are supported by evidence and are simple, such as appropriate hand hygiene, use of full barrier precautions, avoidance of femoral lines, skin antisepsis, and removal of unnecessary lines. The most successful and sustained improvements in CLABSI rates further utilize an adaptive component to align provider behaviors with consistent and reliable use of evidence-based practices. Great success has been achieved in reducing CLABSI rates in the USA and elsewhere over the past decade, but more is needed. This article aims to review the initiatives undertaken to reduce CLABSI and summarizes the sentinel and recent literature regarding CLABSI and its prevention.

Original languageEnglish
Article number35
JournalCurrent Infectious Disease Reports
Issue number7
Publication statusPublished - 4 Jul 2015
Externally publishedYes


  • Best practices
  • Central line-associated bloodstream infection
  • Critical care
  • Healthcare-acquired infections
  • Patient safety
  • Quality improvement


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