Endocrine complications in patients of beta thalassemia major in a tertiary care hospital in Pakistan

Amina Adil, Zain A. Sobani, Abdul Jabbar, Salman N. Adil, Safia Awan

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Objective: To determine the major endocrine complications present in patients of Thalassemia major presenting to a tertiary care center in Karachi, Pakistan. Methods: Records of all thallasemia major patients at a Haematology Department in a tertiary care hospital of Karachi were retrospectively reviewed from May to August 2009 with specific focus on endocrine data and investigations. The patients' data was recorded in a questionnaire and analyzed using SPSS v.17, frequencies and percentages along with corresponding 95% confidence interval were computed. Results: Our data revealed that a significantly small percentage of those under care received regular endocrine follow-up. Male hypo-gonadal abnormalities had the highest probability; 100% of the tested patients had decreased levels of testosterone, while 95.2% had raised serum creatinine levels. Parathyroid dysfunction was noted in 40% of the patients. Of those screened 29.4% had blood glucose levels in the diabetic range and 11.8% of the tested patients had reduced levels of FT4. Conclusion: A high frequency at endocrine dysfunctions seen in thalasaemia patients included: male hypogonadism, parathyroid dysfunction, deranged blood glucose and FT4 levles.

Original languageEnglish
Pages (from-to)307-310
Number of pages4
JournalJournal of the Pakistan Medical Association
Issue number3
Publication statusPublished - Mar 2012


  • Endocrine disorders
  • Serum feritin
  • Thalassaemia


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