Endometriosis, infertility and MicroRNA's: A review

Medical Student Mohummad Hasan Raza Raja, Research Associate Nida Farooqui, Associate Professor Dr Nadeem Zuberi, Senior Technologist Mussarat Ashraf, Senior Instructor Dr Arfa Azhar, Research Associate Rozeena Baig, Medical Student Bisma Badar, Associate Professor Dr Rehana Rehman

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.

Original languageEnglish
Article number102157
JournalJournal of Gynecology Obstetrics and Human Reproduction
Volume50
Issue number9
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Angiogenesis
  • Endometriosis
  • Infertility
  • Inflammation
  • Micro RNA
  • Oxidative stress

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