Endometriosis, infertility and MicroRNA's: A review

Medical Student Mohummad Hasan Raza Raja; Research Associate Nida Farooqui; Associate Professor Dr Nadeem Zuberi; Senior Technologist Mussarat Ashraf; Senior Instructor Dr Arfa Azhar; Research Associate Rozeena Baig; Medical Student Bisma Badar; Associate Professor Dr Rehana Rehman

doi:10.1016/j.jogoh.2021.102157

Endometriosis, infertility and MicroRNA's: A review

Medical Student Mohummad Hasan Raza Raja
, Research Associate Nida Farooqui
, Associate Professor Dr Nadeem Zuberi
, Senior Technologist Mussarat Ashraf
, Senior Instructor Dr Arfa Azhar
, Research Associate Rozeena Baig
, Medical Student Bisma Badar
, Associate Professor Dr Rehana Rehman

Department of Biological & Biomedical Sciences, Medical College, Pakistan

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Abstract

The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.

Original language	English (UK)
Article number	102157
Journal	Journal of Gynecology Obstetrics and Human Reproduction
Volume	50
Issue number	9
DOIs	https://doi.org/10.1016/j.jogoh.2021.102157
Publication status	Published - Nov 2021

Keywords

Angiogenesis
Endometriosis
Infertility
Inflammation
Micro RNA
Oxidative stress

Access to Document

10.1016/j.jogoh.2021.102157

Cite this

@article{5281fc2caace46109e4f90463c5a618c,

title = "Endometriosis, infertility and MicroRNA's: A review",

abstract = "The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.",

keywords = "Angiogenesis, Endometriosis, Infertility, Inflammation, Micro RNA, Oxidative stress",

author = "Raja, \{Medical Student Mohummad Hasan Raza\} and Farooqui, \{Research Associate Nida\} and Zuberi, \{Associate Professor Dr Nadeem\} and Ashraf, \{Senior Technologist Mussarat\} and Azhar, \{Senior Instructor Dr Arfa\} and Baig, \{Research Associate Rozeena\} and Badar, \{Medical Student Bisma\} and Rehman, \{Associate Professor Dr Rehana\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Masson SAS",

year = "2021",

month = nov,

doi = "10.1016/j.jogoh.2021.102157",

language = "English (UK)",

volume = "50",

journal = "Journal of Gynecology Obstetrics and Human Reproduction",

issn = "0368-2315",

publisher = "Elsevier Masson s.r.l.",

number = "9",

}

TY - JOUR

T1 - Endometriosis, infertility and MicroRNA's

T2 - A review

AU - Raja, Medical Student Mohummad Hasan Raza

AU - Farooqui, Research Associate Nida

AU - Zuberi, Associate Professor Dr Nadeem

AU - Ashraf, Senior Technologist Mussarat

AU - Azhar, Senior Instructor Dr Arfa

AU - Baig, Research Associate Rozeena

AU - Badar, Medical Student Bisma

AU - Rehman, Associate Professor Dr Rehana

PY - 2021/11

Y1 - 2021/11

N2 - The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.

AB - The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.

KW - Angiogenesis

KW - Endometriosis

KW - Infertility

KW - Inflammation

KW - Micro RNA

KW - Oxidative stress

UR - https://www.scopus.com/pages/publications/85105973333

U2 - 10.1016/j.jogoh.2021.102157

DO - 10.1016/j.jogoh.2021.102157

M3 - Review article

C2 - 33957270

AN - SCOPUS:85105973333

SN - 0368-2315

VL - 50

JO - Journal of Gynecology Obstetrics and Human Reproduction

JF - Journal of Gynecology Obstetrics and Human Reproduction

IS - 9

M1 - 102157

ER -

Endometriosis, infertility and MicroRNA's: A review

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this