TY - JOUR
T1 - Endometriosis, infertility and MicroRNA's
T2 - A review
AU - Raja, Medical Student Mohummad Hasan Raza
AU - Farooqui, Research Associate Nida
AU - Zuberi, Associate Professor Dr Nadeem
AU - Ashraf, Senior Technologist Mussarat
AU - Azhar, Senior Instructor Dr Arfa
AU - Baig, Research Associate Rozeena
AU - Badar, Medical Student Bisma
AU - Rehman, Associate Professor Dr Rehana
N1 - Publisher Copyright:
© 2021 Elsevier Masson SAS
PY - 2021/11
Y1 - 2021/11
N2 - The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.
AB - The review aims to explore circulating small non- coding regulatory Ribonucleic Acids (miRNA) as biomarkers of endometriosis; a reproductive age group disorder. miRNA are linked with genetic, epigenetic and angiogenic factors, hormones, cytokines, chemokines, oxidative stress (OS) markers, mediators of inflammation, hypoxia, angiogenesis and altered immune system contributing to the pathogenesis of endometriosis. Hormonal imbalance occurs by decreased levels of miRNAs -23a and miRNAs -23b and increase in miRNAs -:135a, 135b, 29c and 194–3p. Angiogenesis by vascular endothelial growth factor is attributed to increased miRNAs -126, miRNAs -210, miRNAs -21, miRNAs -199a-5p and miRNAs 20A. OS upregulates miRNAs -302a by increased levels of Tumor Necrosis factor (TNF)-α, TNF- β and Interleukin -1β. Upregulation of miRNAs -199a and miRNAs -16 promotes inflammation and cell proliferation in the endometriotic lesions.
KW - Angiogenesis
KW - Endometriosis
KW - Infertility
KW - Inflammation
KW - Micro RNA
KW - Oxidative stress
UR - https://www.scopus.com/pages/publications/85105973333
U2 - 10.1016/j.jogoh.2021.102157
DO - 10.1016/j.jogoh.2021.102157
M3 - Review article
C2 - 33957270
AN - SCOPUS:85105973333
SN - 0368-2315
VL - 50
JO - Journal of Gynecology Obstetrics and Human Reproduction
JF - Journal of Gynecology Obstetrics and Human Reproduction
IS - 9
M1 - 102157
ER -