Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus

Philippa C. Matthews; Ponsiano Ocama; Su Wang; Manal El-Sayed; Anna Turkova; Deborah Ford; Judith Torimiro; Ana Cristina Garcia Ferreira; Angélica Espinosa Miranda; Fernando Pio De La Hoz Restrepo; Emmanuel Seremba; Robinson Mbu; Calvin Q. Pan; Homie Razavi; Geoffrey Dusheiko; C. Wendy Spearman; Saeed Hamid

doi:10.1016/j.jhepr.2023.100777

Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus

Philippa C. Matthews, Ponsiano Ocama, Su Wang, Manal El-Sayed, Anna Turkova, Deborah Ford, Judith Torimiro, Ana Cristina Garcia Ferreira, Angélica Espinosa Miranda, Fernando Pio De La Hoz Restrepo, Emmanuel Seremba, Robinson Mbu, Calvin Q. Pan, Homie Razavi, Geoffrey Dusheiko, C. Wendy Spearman, Saeed Hamid

Department of Medicine, Medical College, Pakistan

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

Prevention of mother-to-child transmission of hepatitis B virus (HBV) infection is a cornerstone of efforts to support progress towards elimination of viral hepatitis. Current guidelines recommend maternal screening, antiviral therapy during the third trimester of high-risk pregnancies, universal and timely HBV birth dose vaccination, and post-exposure prophylaxis with hepatitis B immunoglobulin for selected neonates. However, serological and molecular diagnostic testing, treatment and HBV vaccination are not consistently deployed, particularly in many high endemicity settings, and models predict that global targets for reduction in paediatric incidence will not be met by 2030. In this article, we briefly summarise the evidence for current practice and use this as a basis to discuss areas in which prevention of mother-to-child transmission can potentially be enhanced. By reducing health inequities, enhancing pragmatic use of resources, filling data gaps, developing advocacy and education, and seeking consistent investment from multilateral agencies, significant advances can be made to further reduce vertical transmission events, with wide health, societal and economic benefits.

Original language	English
Article number	100777
Journal	JHEP Reports
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/j.jhepr.2023.100777
Publication status	Published - Aug 2023

Keywords

HBIG
HBV
PMTCT
birth dose
elimination
hepatitis B virus
prevention
tenofovir
transmission
vaccination
vertical transmission

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jhepr.2023.100777

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Matthews, P. C., Ocama, P., Wang, S., El-Sayed, M., Turkova, A., Ford, D., Torimiro, J., Garcia Ferreira, A. C., Espinosa Miranda, A., De La Hoz Restrepo, F. P., Seremba, E., Mbu, R., Pan, C. Q., Razavi, H., Dusheiko, G., Spearman, C. W., & Hamid, S. (2023). Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus. JHEP Reports, 5(8), Article 100777. https://doi.org/10.1016/j.jhepr.2023.100777

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title = "Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus",

abstract = "Prevention of mother-to-child transmission of hepatitis B virus (HBV) infection is a cornerstone of efforts to support progress towards elimination of viral hepatitis. Current guidelines recommend maternal screening, antiviral therapy during the third trimester of high-risk pregnancies, universal and timely HBV birth dose vaccination, and post-exposure prophylaxis with hepatitis B immunoglobulin for selected neonates. However, serological and molecular diagnostic testing, treatment and HBV vaccination are not consistently deployed, particularly in many high endemicity settings, and models predict that global targets for reduction in paediatric incidence will not be met by 2030. In this article, we briefly summarise the evidence for current practice and use this as a basis to discuss areas in which prevention of mother-to-child transmission can potentially be enhanced. By reducing health inequities, enhancing pragmatic use of resources, filling data gaps, developing advocacy and education, and seeking consistent investment from multilateral agencies, significant advances can be made to further reduce vertical transmission events, with wide health, societal and economic benefits.",

keywords = "HBIG, HBV, PMTCT, birth dose, elimination, hepatitis B virus, prevention, tenofovir, transmission, vaccination, vertical transmission",

author = "Matthews, {Philippa C.} and Ponsiano Ocama and Su Wang and Manal El-Sayed and Anna Turkova and Deborah Ford and Judith Torimiro and {Garcia Ferreira}, {Ana Cristina} and {Espinosa Miranda}, Ang{\'e}lica and {De La Hoz Restrepo}, {Fernando Pio} and Emmanuel Seremba and Robinson Mbu and Pan, {Calvin Q.} and Homie Razavi and Geoffrey Dusheiko and Spearman, {C. Wendy} and Saeed Hamid",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = aug,

doi = "10.1016/j.jhepr.2023.100777",

language = "English",

volume = "5",

journal = "JHEP Reports",

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Matthews, PC, Ocama, P, Wang, S, El-Sayed, M, Turkova, A, Ford, D, Torimiro, J, Garcia Ferreira, AC, Espinosa Miranda, A, De La Hoz Restrepo, FP, Seremba, E, Mbu, R, Pan, CQ, Razavi, H, Dusheiko, G, Spearman, CW & Hamid, S 2023, 'Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus', JHEP Reports, vol. 5, no. 8, 100777. https://doi.org/10.1016/j.jhepr.2023.100777

TY - JOUR

T1 - Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus

AU - Matthews, Philippa C.

AU - Ocama, Ponsiano

AU - Wang, Su

AU - El-Sayed, Manal

AU - Turkova, Anna

AU - Ford, Deborah

AU - Torimiro, Judith

AU - Garcia Ferreira, Ana Cristina

AU - Espinosa Miranda, Angélica

AU - De La Hoz Restrepo, Fernando Pio

AU - Seremba, Emmanuel

AU - Mbu, Robinson

AU - Pan, Calvin Q.

AU - Razavi, Homie

AU - Dusheiko, Geoffrey

AU - Spearman, C. Wendy

AU - Hamid, Saeed

PY - 2023/8

Y1 - 2023/8

N2 - Prevention of mother-to-child transmission of hepatitis B virus (HBV) infection is a cornerstone of efforts to support progress towards elimination of viral hepatitis. Current guidelines recommend maternal screening, antiviral therapy during the third trimester of high-risk pregnancies, universal and timely HBV birth dose vaccination, and post-exposure prophylaxis with hepatitis B immunoglobulin for selected neonates. However, serological and molecular diagnostic testing, treatment and HBV vaccination are not consistently deployed, particularly in many high endemicity settings, and models predict that global targets for reduction in paediatric incidence will not be met by 2030. In this article, we briefly summarise the evidence for current practice and use this as a basis to discuss areas in which prevention of mother-to-child transmission can potentially be enhanced. By reducing health inequities, enhancing pragmatic use of resources, filling data gaps, developing advocacy and education, and seeking consistent investment from multilateral agencies, significant advances can be made to further reduce vertical transmission events, with wide health, societal and economic benefits.

AB - Prevention of mother-to-child transmission of hepatitis B virus (HBV) infection is a cornerstone of efforts to support progress towards elimination of viral hepatitis. Current guidelines recommend maternal screening, antiviral therapy during the third trimester of high-risk pregnancies, universal and timely HBV birth dose vaccination, and post-exposure prophylaxis with hepatitis B immunoglobulin for selected neonates. However, serological and molecular diagnostic testing, treatment and HBV vaccination are not consistently deployed, particularly in many high endemicity settings, and models predict that global targets for reduction in paediatric incidence will not be met by 2030. In this article, we briefly summarise the evidence for current practice and use this as a basis to discuss areas in which prevention of mother-to-child transmission can potentially be enhanced. By reducing health inequities, enhancing pragmatic use of resources, filling data gaps, developing advocacy and education, and seeking consistent investment from multilateral agencies, significant advances can be made to further reduce vertical transmission events, with wide health, societal and economic benefits.

KW - HBIG

KW - HBV

KW - PMTCT

KW - birth dose

KW - elimination

KW - hepatitis B virus

KW - prevention

KW - tenofovir

KW - transmission

KW - vaccination

KW - vertical transmission

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U2 - 10.1016/j.jhepr.2023.100777

DO - 10.1016/j.jhepr.2023.100777

M3 - Review article

AN - SCOPUS:85164398621

SN - 2589-5559

VL - 5

JO - JHEP Reports

JF - JHEP Reports

IS - 8

M1 - 100777

ER -

Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus

Abstract

Keywords

UN SDGs

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