Enteropathogenic and enteroaggregative E. coli in stools of children with acute gastroenteritis in Davidson County, Tennessee

Monique A. Foster, Junaid Iqbal, Chengxian Zhang, Rendie McHenry, Brent E. Cleveland, Yesenia Romero-Herazo, Chris Fonnesbeck, Daniel C. Payne, James D. Chappell, Natasha Halasa, Oscar G. Gómez-Duarte

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

This prospective acute gastroenteritis (AGE) surveillance was conducted in the inpatient and emergency room settings at a referral pediatric hospital to determine the prevalence of diarrheagenic Escherichia coli (DEC) in children <12. years of age with AGE in Davidson County, Tennessee. Subjects 15 days to 11 years of age, who presented with diarrhea and/or vomiting, were enrolled. Stool specimens were processed for detection of DEC using multiplex polymerase chain reaction. From December 1, 2011, to June 30, 2012, a total of 79 (38%) out of 206 stool specimens from children with AGE tested positive for E. coli. A total of 12 (5.8%) out of 206 stool specimens from children with AGE were positive for a DEC. Eight (67%) out of these 12 were positive for enteropathogenic E. coli, and the remaining 4 were positive for enteroaggregative E. coli. DEC clinical isolates clustered with known E. coli enteropathogens according to multilocus sequencing typing.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume83
Issue number3
DOIs
Publication statusPublished - Nov 2015
Externally publishedYes

Keywords

  • Children
  • Diarrhea
  • E. coli
  • EAEC
  • EPEC
  • Epidemiology
  • Gastroenteritis

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