ERG oncoprotein expression in prostatic acinar adenocarcinoma; Clinicopathologic significance

Atif Ali Hashmi, Erum Yousuf Khan, Muhammad Irfan, Rabia Ali, Huda Asif, Maheen Naeem, Laila Nisar, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objectives: T/E fusion results in constitutive expression of ERG oncoprotein resulting in enhanced proliferation and invasive potential of prostatic cancer cells. In the present study we aimed to evaluate the ERG overexpression in 78 cases prostate acinar adenocarcinoma and its association with other prognostic parameters. Results: ERG protein expression was noted in 39.7% (31 cases), out of which 3 cases (3.8%) showed low ERG expression, 10 cases (12.8%) showed intermediate expression and 18 cases (23.1%) revealed high ERG expression. Significant association of ERG expression was noted with gleason score (p = 0.009), WHO grade group (p = 0.008) and perineural invasion (p = 0.043). We found a significant proportion of our patients of prostatic acinar adenocarcinoma to over-express ERG protein which can help in devising therapeutic protocols. Significant association of ERG protein expression with gleason score and perineural invasion signifies its prognostic significance in prostatic carcinoma. Moreover, we also suggest that molecular studies should be performed in patients with prostatic carcinoma to look for T/E fusion gene and its correlation with ERG protein expression.

Original languageEnglish
Article number35
JournalBMC Research Notes
Issue number1
Publication statusPublished - 18 Jan 2019
Externally publishedYes


  • ERG oncoprotein
  • Gleason score
  • Immunohistochemistry
  • Prostatic adenocarcinoma
  • WHO grade group


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