Ethnopharmacological studies on Chrozophora prostrata in perspective of its folkloric reputation as purgative

Usman Arshad, Khalid Hussain Janbaz, Samra Bashir, Najeeb-ur-Rehman, Malik Hassan Mehmood, Anwar ul Hassan Gilani

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7 Citations (Scopus)


This study was undertaken to validate the medicinal use of Chrozophora prostrata in constipation. The crude extract of C prostrata produced laxative effect in mice at 100 and 300 mg/kg, similar to carbachol and castor oil. In spontaneously contracting rabbit jejunum tissues, C. prostrata (0.01-3 mg/mL) exhibited atropine-sensitive spasmogenic effect, which was reproducible in guinea-pig ileum. Interestingly, at high concentrations, C. prostrata showed concentration-dependent inhibitory effect on rabbit jejunum, suggesting the presence of accompanied spasmolytic activity. When tested on induced contractions, C. prostrata completely relaxed low K+-induced contraction, while partially inhibited high K+, similar to cromakalim. Tetraethylammonium pretreatment abolished the relaxant effect of C. prostrata on low K+-induced contractions while glibenclamide caused partial inhibition, suggesting the involvement of some non-specific and ATP-dependent K+ channels. These data show that C. prostrata possesses laxative effect at low doses mediated through cholinergic action followed by the spasmolytic activity at high doses mediated possibly through K+ channel activation.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalBangladesh Journal of Pharmacology
Issue number4
Publication statusPublished - 2012
Externally publishedYes


  • Cholinergic
  • Chrozophora prostrate
  • K channel opener
  • Purgative
  • Spasmolytic


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