Etiology of bacteremia in young infants in six countries

Davidson H. Hamer; Gary L. Darmstadt; John B. Carlin; Anita K.M. Zaidi; Kojo Yeboah-Antwi; Samir K. Saha; Pallab Ray; Anil Narang; Eduardo Mazzi; Praveen Kumar; Arti Kapil; Prakash M. Jeena; Ashok Deorari; A. K.Azad Chowdury; Andres Bartos; Zulfiqar A. Bhutta; Yaw Adu-Sarkodie; Miriam Adhikari; Emmanuel Addo-Yobo; Martin W. Weber; A. K. Azad Chowdhury; A. S.M. Nawshad Uddin Ahmed; Md Monir Hossain; Nazmun Nahar; Amala Baidya; Mahmuda Parul; Maksuda Islam; Tania Nasreen; Md Rezaur Rahaman; Teresa Villagomez; Pablo Mattos; Manuel Pantoja Ludueña; Remedios Zumarán; Irma Quispe; Willy Tarqui; Lourdes Checa; Claudia Canqui; Erick Dueñas; Omar Vargas; Emmanuel Addo Yobo; G. Plange-Rhule; Osei Akoto; M. Lartey; Henrietta Akpene; Rupinder Narang; Prasad Muley; Satish Misra; Rani Sanjay Tapasaya; Tamanna Gaur; Vishal Kanojia; Ajay Dogra; Harish Chellani; M. S. Prasad; A. Satyavani; Jyoti Raji John; Sanjeev Negi; Narinder Singhal; Shiyam Sunder; Shazia Sultana; Shazia Azeem; Razzaq Lasi; Farrukh Abbasi; Razia Sultana; Nasira A. Jabbar; Rumina Hasan; Arjumand Rizvi; Durrane Thaver; Sister Mojaphelo; Wim Sturm; Precious Sikhakhane.; Rajiv Bahl; Kim Mulholland; Vinod Paul; Eric Simoes; Jelka Zupan; Philip Greenwood; Claudine Chionh

doi:10.1097/INF.0000000000000549

Etiology of bacteremia in young infants in six countries

Davidson H. Hamer, Gary L. Darmstadt, John B. Carlin, Anita K.M. Zaidi, Kojo Yeboah-Antwi, Samir K. Saha, Pallab Ray, Anil Narang, Eduardo Mazzi, Praveen Kumar, Arti Kapil, Prakash M. Jeena, Ashok Deorari, A. K.Azad Chowdury, Andres Bartos, Zulfiqar A. Bhutta, Yaw Adu-Sarkodie, Miriam Adhikari, Emmanuel Addo-Yobo, Martin W. WeberA. K. Azad Chowdhury, A. S.M. Nawshad Uddin Ahmed, Md Monir Hossain, Nazmun Nahar, Amala Baidya, Mahmuda Parul, Maksuda Islam, Tania Nasreen, Md Rezaur Rahaman, Teresa Villagomez, Pablo Mattos, Manuel Pantoja Ludueña, Remedios Zumarán, Irma Quispe, Willy Tarqui, Lourdes Checa, Claudia Canqui, Erick Dueñas, Omar Vargas, Emmanuel Addo Yobo, G. Plange-Rhule, Osei Akoto, M. Lartey, Henrietta Akpene, Rupinder Narang, Prasad Muley, Satish Misra, Rani Sanjay Tapasaya, Tamanna Gaur, Vishal Kanojia, Ajay Dogra, Harish Chellani, M. S. Prasad, A. Satyavani, Jyoti Raji John, Sanjeev Negi, Narinder Singhal, Shiyam Sunder, Shazia Sultana, Shazia Azeem, Razzaq Lasi, Farrukh Abbasi, Razia Sultana, Nasira A. Jabbar, Rumina Hasan, Arjumand Rizvi, Durrane Thaver, Sister Mojaphelo, Wim Sturm, Precious Sikhakhane., Rajiv Bahl, Kim Mulholland, Vinod Paul, Eric Simoes, Jelka Zupan, Philip Greenwood, Claudine Chionh

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Abstract

Background: Neonatal illness is a leading cause of death worldwide; sepsis is one of the main contributors. The etiologies of community-acquired neonatal bacteremia in developing countries have not been well characterized. Methods: Infants <2 months of age brought with illness to selected health facilities in Bangladesh, Bolivia, Ghana, India, Pakistan and South Africa were evaluated, and blood cultures taken if they were considered ill enough to be admitted to hospital. Organisms were isolated using standard culture techniques. Results: Eight thousand eight hundred and eighty-nine infants were recruited, including 3177 0-6 days of age and 5712 7-59 days of age; 10.7% (947/8889) had a blood culture performed. Of those requiring hospital management, 782 (54%) had blood cultures performed. Probable or definite pathogens were identified in 10.6% including 10.4% of newborns 0-6 days of age (44/424) and 10.9% of infants 7-59 days of age (39/358). Staphylococcus aureus was the most commonly isolated species (36/83, 43.4%) followed by various species of Gram-negative bacilli (39/83, 46.9%; Acinetobacter spp., Escherichia coli and Klebsiella spp. were the most common organisms). Resistance to second and third generation cephalosporins was present in more than half of isolates and 44% of the Gram-negative isolates were gentamicin-resistant. Mortality rates were similar in hospitalized infants with positive (5/71, 7.0%) and negative blood cultures (42/557, 7.5%). Conclusions: This large study of young infants aged 0-59 days demonstrated a broad array of Gram-positive and Gram-negative pathogens responsible for community-acquired bacteremia and substantial levels of antimicrobial resistance. The role of S. aureus as a pathogen is unclear and merits further investigation.

Original language	English
Pages (from-to)	e1-e8
Journal	Pediatric Infectious Disease Journal
Volume	34
Issue number	1
DOIs	https://doi.org/10.1097/INF.0000000000000549
Publication status	Published - 2015

Keywords

Bacteremia
Infant
Neonatal sepsis
Neonate
Staphylococcus aureus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000000549

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Hamer, D. H., Darmstadt, G. L., Carlin, J. B., Zaidi, A. K. M., Yeboah-Antwi, K., Saha, S. K., Ray, P., Narang, A., Mazzi, E., Kumar, P., Kapil, A., Jeena, P. M., Deorari, A., Chowdury, A. K. A., Bartos, A., Bhutta, Z. A., Adu-Sarkodie, Y., Adhikari, M., Addo-Yobo, E., ... Chionh, C. (2015). Etiology of bacteremia in young infants in six countries. Pediatric Infectious Disease Journal, 34(1), e1-e8. https://doi.org/10.1097/INF.0000000000000549

@article{145c59763d0d479fb492af7584ff54ba,

title = "Etiology of bacteremia in young infants in six countries",

abstract = "Background: Neonatal illness is a leading cause of death worldwide; sepsis is one of the main contributors. The etiologies of community-acquired neonatal bacteremia in developing countries have not been well characterized. Methods: Infants <2 months of age brought with illness to selected health facilities in Bangladesh, Bolivia, Ghana, India, Pakistan and South Africa were evaluated, and blood cultures taken if they were considered ill enough to be admitted to hospital. Organisms were isolated using standard culture techniques. Results: Eight thousand eight hundred and eighty-nine infants were recruited, including 3177 0-6 days of age and 5712 7-59 days of age; 10.7% (947/8889) had a blood culture performed. Of those requiring hospital management, 782 (54%) had blood cultures performed. Probable or definite pathogens were identified in 10.6% including 10.4% of newborns 0-6 days of age (44/424) and 10.9% of infants 7-59 days of age (39/358). Staphylococcus aureus was the most commonly isolated species (36/83, 43.4%) followed by various species of Gram-negative bacilli (39/83, 46.9%; Acinetobacter spp., Escherichia coli and Klebsiella spp. were the most common organisms). Resistance to second and third generation cephalosporins was present in more than half of isolates and 44% of the Gram-negative isolates were gentamicin-resistant. Mortality rates were similar in hospitalized infants with positive (5/71, 7.0%) and negative blood cultures (42/557, 7.5%). Conclusions: This large study of young infants aged 0-59 days demonstrated a broad array of Gram-positive and Gram-negative pathogens responsible for community-acquired bacteremia and substantial levels of antimicrobial resistance. The role of S. aureus as a pathogen is unclear and merits further investigation.",

keywords = "Bacteremia, Infant, Neonatal sepsis, Neonate, Staphylococcus aureus",

author = "Hamer, {Davidson H.} and Darmstadt, {Gary L.} and Carlin, {John B.} and Zaidi, {Anita K.M.} and Kojo Yeboah-Antwi and Saha, {Samir K.} and Pallab Ray and Anil Narang and Eduardo Mazzi and Praveen Kumar and Arti Kapil and Jeena, {Prakash M.} and Ashok Deorari and Chowdury, {A. K.Azad} and Andres Bartos and Bhutta, {Zulfiqar A.} and Yaw Adu-Sarkodie and Miriam Adhikari and Emmanuel Addo-Yobo and Weber, {Martin W.} and {Azad Chowdhury}, {A. K.} and {Nawshad Uddin Ahmed}, {A. S.M.} and Hossain, {Md Monir} and Nazmun Nahar and Amala Baidya and Mahmuda Parul and Maksuda Islam and Tania Nasreen and Rahaman, {Md Rezaur} and Teresa Villagomez and Pablo Mattos and Ludue{\~n}a, {Manuel Pantoja} and Remedios Zumar{\'a}n and Irma Quispe and Willy Tarqui and Lourdes Checa and Claudia Canqui and Erick Due{\~n}as and Omar Vargas and Yobo, {Emmanuel Addo} and G. Plange-Rhule and Osei Akoto and M. Lartey and Henrietta Akpene and Rupinder Narang and Prasad Muley and Satish Misra and Tapasaya, {Rani Sanjay} and Tamanna Gaur and Vishal Kanojia and Ajay Dogra and Harish Chellani and Prasad, {M. S.} and A. Satyavani and John, {Jyoti Raji} and Sanjeev Negi and Narinder Singhal and Shiyam Sunder and Shazia Sultana and Shazia Azeem and Razzaq Lasi and Farrukh Abbasi and Razia Sultana and Jabbar, {Nasira A.} and Rumina Hasan and Arjumand Rizvi and Durrane Thaver and Sister Mojaphelo and Wim Sturm and Precious Sikhakhane. and Rajiv Bahl and Kim Mulholland and Vinod Paul and Eric Simoes and Jelka Zupan and Philip Greenwood and Claudine Chionh",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 by Lippincott Williams & Wilkins.",

year = "2015",

doi = "10.1097/INF.0000000000000549",

language = "English",

volume = "34",

pages = "e1--e8",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "1",

}

Hamer, DH, Darmstadt, GL, Carlin, JB, Zaidi, AKM, Yeboah-Antwi, K, Saha, SK, Ray, P, Narang, A, Mazzi, E, Kumar, P, Kapil, A, Jeena, PM, Deorari, A, Chowdury, AKA, Bartos, A, Bhutta, ZA, Adu-Sarkodie, Y, Adhikari, M, Addo-Yobo, E, Weber, MW, Azad Chowdhury, AK, Nawshad Uddin Ahmed, ASM, Hossain, MM, Nahar, N, Baidya, A, Parul, M, Islam, M, Nasreen, T, Rahaman, MR, Villagomez, T, Mattos, P, Ludueña, MP, Zumarán, R, Quispe, I, Tarqui, W, Checa, L, Canqui, C, Dueñas, E, Vargas, O, Yobo, EA, Plange-Rhule, G, Akoto, O, Lartey, M, Akpene, H, Narang, R, Muley, P, Misra, S, Tapasaya, RS, Gaur, T, Kanojia, V, Dogra, A, Chellani, H, Prasad, MS, Satyavani, A, John, JR, Negi, S, Singhal, N, Sunder, S, Sultana, S, Azeem, S, Lasi, R, Abbasi, F, Sultana, R, Jabbar, NA, Hasan, R, Rizvi, A, Thaver, D, Mojaphelo, S, Sturm, W, Sikhakhane., P, Bahl, R, Mulholland, K, Paul, V, Simoes, E, Zupan, J, Greenwood, P & Chionh, C 2015, 'Etiology of bacteremia in young infants in six countries', Pediatric Infectious Disease Journal, vol. 34, no. 1, pp. e1-e8. https://doi.org/10.1097/INF.0000000000000549

TY - JOUR

T1 - Etiology of bacteremia in young infants in six countries

AU - Hamer, Davidson H.

AU - Darmstadt, Gary L.

AU - Carlin, John B.

AU - Zaidi, Anita K.M.

AU - Yeboah-Antwi, Kojo

AU - Saha, Samir K.

AU - Ray, Pallab

AU - Narang, Anil

AU - Mazzi, Eduardo

AU - Kumar, Praveen

AU - Kapil, Arti

AU - Jeena, Prakash M.

AU - Deorari, Ashok

AU - Chowdury, A. K.Azad

AU - Bartos, Andres

AU - Bhutta, Zulfiqar A.

AU - Adu-Sarkodie, Yaw

AU - Adhikari, Miriam

AU - Addo-Yobo, Emmanuel

AU - Weber, Martin W.

AU - Azad Chowdhury, A. K.

AU - Nawshad Uddin Ahmed, A. S.M.

AU - Hossain, Md Monir

AU - Nahar, Nazmun

AU - Baidya, Amala

AU - Parul, Mahmuda

AU - Islam, Maksuda

AU - Nasreen, Tania

AU - Rahaman, Md Rezaur

AU - Villagomez, Teresa

AU - Mattos, Pablo

AU - Ludueña, Manuel Pantoja

AU - Zumarán, Remedios

AU - Quispe, Irma

AU - Tarqui, Willy

AU - Checa, Lourdes

AU - Canqui, Claudia

AU - Dueñas, Erick

AU - Vargas, Omar

AU - Yobo, Emmanuel Addo

AU - Plange-Rhule, G.

AU - Akoto, Osei

AU - Lartey, M.

AU - Akpene, Henrietta

AU - Narang, Rupinder

AU - Muley, Prasad

AU - Misra, Satish

AU - Tapasaya, Rani Sanjay

AU - Gaur, Tamanna

AU - Kanojia, Vishal

AU - Dogra, Ajay

AU - Chellani, Harish

AU - Prasad, M. S.

AU - Satyavani, A.

AU - John, Jyoti Raji

AU - Negi, Sanjeev

AU - Singhal, Narinder

AU - Sunder, Shiyam

AU - Sultana, Shazia

AU - Azeem, Shazia

AU - Lasi, Razzaq

AU - Abbasi, Farrukh

AU - Sultana, Razia

AU - Jabbar, Nasira A.

AU - Hasan, Rumina

AU - Rizvi, Arjumand

AU - Thaver, Durrane

AU - Mojaphelo, Sister

AU - Sturm, Wim

AU - Sikhakhane., Precious

AU - Bahl, Rajiv

AU - Mulholland, Kim

AU - Paul, Vinod

AU - Simoes, Eric

AU - Zupan, Jelka

AU - Greenwood, Philip

AU - Chionh, Claudine

PY - 2015

Y1 - 2015

N2 - Background: Neonatal illness is a leading cause of death worldwide; sepsis is one of the main contributors. The etiologies of community-acquired neonatal bacteremia in developing countries have not been well characterized. Methods: Infants <2 months of age brought with illness to selected health facilities in Bangladesh, Bolivia, Ghana, India, Pakistan and South Africa were evaluated, and blood cultures taken if they were considered ill enough to be admitted to hospital. Organisms were isolated using standard culture techniques. Results: Eight thousand eight hundred and eighty-nine infants were recruited, including 3177 0-6 days of age and 5712 7-59 days of age; 10.7% (947/8889) had a blood culture performed. Of those requiring hospital management, 782 (54%) had blood cultures performed. Probable or definite pathogens were identified in 10.6% including 10.4% of newborns 0-6 days of age (44/424) and 10.9% of infants 7-59 days of age (39/358). Staphylococcus aureus was the most commonly isolated species (36/83, 43.4%) followed by various species of Gram-negative bacilli (39/83, 46.9%; Acinetobacter spp., Escherichia coli and Klebsiella spp. were the most common organisms). Resistance to second and third generation cephalosporins was present in more than half of isolates and 44% of the Gram-negative isolates were gentamicin-resistant. Mortality rates were similar in hospitalized infants with positive (5/71, 7.0%) and negative blood cultures (42/557, 7.5%). Conclusions: This large study of young infants aged 0-59 days demonstrated a broad array of Gram-positive and Gram-negative pathogens responsible for community-acquired bacteremia and substantial levels of antimicrobial resistance. The role of S. aureus as a pathogen is unclear and merits further investigation.

AB - Background: Neonatal illness is a leading cause of death worldwide; sepsis is one of the main contributors. The etiologies of community-acquired neonatal bacteremia in developing countries have not been well characterized. Methods: Infants <2 months of age brought with illness to selected health facilities in Bangladesh, Bolivia, Ghana, India, Pakistan and South Africa were evaluated, and blood cultures taken if they were considered ill enough to be admitted to hospital. Organisms were isolated using standard culture techniques. Results: Eight thousand eight hundred and eighty-nine infants were recruited, including 3177 0-6 days of age and 5712 7-59 days of age; 10.7% (947/8889) had a blood culture performed. Of those requiring hospital management, 782 (54%) had blood cultures performed. Probable or definite pathogens were identified in 10.6% including 10.4% of newborns 0-6 days of age (44/424) and 10.9% of infants 7-59 days of age (39/358). Staphylococcus aureus was the most commonly isolated species (36/83, 43.4%) followed by various species of Gram-negative bacilli (39/83, 46.9%; Acinetobacter spp., Escherichia coli and Klebsiella spp. were the most common organisms). Resistance to second and third generation cephalosporins was present in more than half of isolates and 44% of the Gram-negative isolates were gentamicin-resistant. Mortality rates were similar in hospitalized infants with positive (5/71, 7.0%) and negative blood cultures (42/557, 7.5%). Conclusions: This large study of young infants aged 0-59 days demonstrated a broad array of Gram-positive and Gram-negative pathogens responsible for community-acquired bacteremia and substantial levels of antimicrobial resistance. The role of S. aureus as a pathogen is unclear and merits further investigation.

KW - Bacteremia

KW - Infant

KW - Neonatal sepsis

KW - Neonate

KW - Staphylococcus aureus

UR - http://www.scopus.com/inward/record.url?scp=84926177156&partnerID=8YFLogxK

U2 - 10.1097/INF.0000000000000549

DO - 10.1097/INF.0000000000000549

M3 - Article

C2 - 25389919

AN - SCOPUS:84926177156

SN - 0891-3668

VL - 34

SP - e1-e8

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 1

ER -

Etiology of bacteremia in young infants in six countries

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Keywords

UN SDGs

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