TY - JOUR
T1 - Evaluating Periodontal Treatment to Prevent Cardiovascular Disease
T2 - Challenges and Possible Solutions
AU - Merchant, Anwar T.
AU - Virani, Salim S.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Purpose of Review: Periodontal disease is correlated with cardiovascular disease (CVD) in observational studies, but a causal connection has not been established. The empirical evidence linking periodontal disease and CVD consists of a large body of observational and mechanistic studies, but a limited number of clinical trials evaluating the effects of periodontal treatment on surrogate CVD endpoints. Recent Findings: No randomized controlled trial has been conducted to evaluate the effect of periodontal treatment on CVD risk. In this review, we have summarized these data, described possible biological mechanisms linking periodontal disease and CVD, discussed barriers to conducting a randomized controlled trial to evaluate this hypothesis, and provided an alternative analytical approach using causal inference methods to answer the question. Summary: The public health implications of addressing this question can be significant because periodontal disease is under-treated, and highly prevalent among adults at risk of CVD. Even a small beneficial effect of periodontal treatment on CVD risk can be important.
AB - Purpose of Review: Periodontal disease is correlated with cardiovascular disease (CVD) in observational studies, but a causal connection has not been established. The empirical evidence linking periodontal disease and CVD consists of a large body of observational and mechanistic studies, but a limited number of clinical trials evaluating the effects of periodontal treatment on surrogate CVD endpoints. Recent Findings: No randomized controlled trial has been conducted to evaluate the effect of periodontal treatment on CVD risk. In this review, we have summarized these data, described possible biological mechanisms linking periodontal disease and CVD, discussed barriers to conducting a randomized controlled trial to evaluate this hypothesis, and provided an alternative analytical approach using causal inference methods to answer the question. Summary: The public health implications of addressing this question can be significant because periodontal disease is under-treated, and highly prevalent among adults at risk of CVD. Even a small beneficial effect of periodontal treatment on CVD risk can be important.
KW - Cardiovascular disease
KW - Causal inference
KW - Periodontal disease
KW - Periodontal treatment
UR - http://www.scopus.com/inward/record.url?scp=85010892485&partnerID=8YFLogxK
U2 - 10.1007/s11883-017-0640-7
DO - 10.1007/s11883-017-0640-7
M3 - Review article
C2 - 28120314
AN - SCOPUS:85010892485
SN - 1523-3804
VL - 19
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 1
M1 - 4
ER -