Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models

P. Wijeweera; J. T. Arnason; D. Koszycki; Z. Merali

doi:10.1016/j.phymed.2006.01.011

Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models

P. Wijeweera, J. T. Arnason, D. Koszycki, Z. Merali

Research output: Contribution to journal › Article › peer-review

138 Citations (Scopus)

Abstract

The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, ethyl acetate and methanol extracts of Gotukola; and asiaticoside, a triterpenic compound isolated from Gotukola. Various paradigms were used to assess the anxiolytic activity, including the elevated plus maze (EPM), open field, social interaction, locomotor activity, punished drinking (Vogel) and novel cage tests. The EPM test revealed that Gotukola, its methanol and ethyl acetate extracts as well as the pure asiaticoside, imparted anxiolytic activity. Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents.

Original language	English
Pages (from-to)	668-676
Number of pages	9
Journal	Phytomedicine
Volume	13
Issue number	9-10
DOIs	https://doi.org/10.1016/j.phymed.2006.01.011
Publication status	Published - 24 Nov 2006
Externally published	Yes

Keywords

Anxiety
Asiaticoside
Elevated plus maze
Gotukola (Centella asiatica)
Locomotor activity
Natural health product
Novel cage
Open field
Rat trial
Social interaction
Vogel

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10.1016/j.phymed.2006.01.011

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title = "Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models",

abstract = "The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, ethyl acetate and methanol extracts of Gotukola; and asiaticoside, a triterpenic compound isolated from Gotukola. Various paradigms were used to assess the anxiolytic activity, including the elevated plus maze (EPM), open field, social interaction, locomotor activity, punished drinking (Vogel) and novel cage tests. The EPM test revealed that Gotukola, its methanol and ethyl acetate extracts as well as the pure asiaticoside, imparted anxiolytic activity. Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents.",

keywords = "Anxiety, Asiaticoside, Elevated plus maze, Gotukola (Centella asiatica), Locomotor activity, Natural health product, Novel cage, Open field, Rat trial, Social interaction, Vogel",

author = "P. Wijeweera and Arnason, {J. T.} and D. Koszycki and Z. Merali",

note = "Funding Information: This study was funded by grants from the International Development Research Centre and the Natural Sciences and Engineering Research Council of Canada. ",

year = "2006",

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doi = "10.1016/j.phymed.2006.01.011",

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AU - Arnason, J. T.

AU - Koszycki, D.

AU - Merali, Z.

N1 - Funding Information: This study was funded by grants from the International Development Research Centre and the Natural Sciences and Engineering Research Council of Canada.

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AB - The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, ethyl acetate and methanol extracts of Gotukola; and asiaticoside, a triterpenic compound isolated from Gotukola. Various paradigms were used to assess the anxiolytic activity, including the elevated plus maze (EPM), open field, social interaction, locomotor activity, punished drinking (Vogel) and novel cage tests. The EPM test revealed that Gotukola, its methanol and ethyl acetate extracts as well as the pure asiaticoside, imparted anxiolytic activity. Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents.

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KW - Asiaticoside

KW - Elevated plus maze

KW - Gotukola (Centella asiatica)

KW - Locomotor activity

KW - Natural health product

KW - Novel cage

KW - Open field

KW - Rat trial

KW - Social interaction

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ER -

Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models

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Keywords

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