Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models

P. Wijeweera, J. T. Arnason, D. Koszycki, Z. Merali

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)

Abstract

The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, ethyl acetate and methanol extracts of Gotukola; and asiaticoside, a triterpenic compound isolated from Gotukola. Various paradigms were used to assess the anxiolytic activity, including the elevated plus maze (EPM), open field, social interaction, locomotor activity, punished drinking (Vogel) and novel cage tests. The EPM test revealed that Gotukola, its methanol and ethyl acetate extracts as well as the pure asiaticoside, imparted anxiolytic activity. Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents.

Original languageEnglish
Pages (from-to)668-676
Number of pages9
JournalPhytomedicine
Volume13
Issue number9-10
DOIs
Publication statusPublished - 24 Nov 2006
Externally publishedYes

Keywords

  • Anxiety
  • Asiaticoside
  • Elevated plus maze
  • Gotukola (Centella asiatica)
  • Locomotor activity
  • Natural health product
  • Novel cage
  • Open field
  • Rat trial
  • Social interaction
  • Vogel

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