Evaluation of pakgen 99mTc generators loaded with indigenous fission 99Mo

A. Mushtaq, S. Pervez, S. Hussain, J. A. Mirza, M. M. Khan, M. Asif, M. U. Siddique, U. Khalid, B. Khan, M. Khalid

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6 Citations (Scopus)


Fission produced 99Mo/ 99mTc generators, called Pakgen, have been manufactured at the PINSTECH generator production facility since 2000 for nuclear medicine applications in Pakistan. These generators were loaded with fission 99Mo imported from NTP South Africa. Recently production of fission 99Mo has begun in the Molybdenum-99 Production Facility at PINSTECH. Prior to use in the clinic, eight sets of generators were produced, 23 GBq and 74 GBq at time of calibration, and they were subjected to various quality control procedures recommended in the pharmacopoeia to assess their performance. The elution profile, volume, activity, pH, radionuclidic, chemical, radiochemical and biological purity, and expiry time of the eluates were examined. Labeling efficiency tests were also carried out with a number of the more widely used in vivo radiopharmaceutical kits like DTPA, MDP and MIBI. Performance of 99mTc generators loaded with locally produced and imported fission 99Mo was comparable, and the users of Pakgen generators were fully satisfied. The effect of a wet vs. a dry column on 99mTc yields of generators loaded with low and high activity was also studied for the first time.

Original languageEnglish
Pages (from-to)793-800
Number of pages8
JournalRadiochimica Acta
Issue number10
Publication statusPublished - 2012
Externally publishedYes


  • Alumina column
  • Expiry time
  • Fission Mo
  • Generator manufacturing
  • Quality control


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