Evolution of Systemic Therapy in Medulloblastoma Including Irradiation-Sparing Approaches

Naureen Mushtaq, Rahat Ul Ain, Syed Ahmer Hamid, Eric Bouffet

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang’s system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review.

Original languageEnglish
Article number3680
Issue number24
Publication statusPublished - Dec 2023


  • chemotherapy
  • high-dose chemotherapy
  • medulloblastoma
  • subgrouping


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