Examining the role of the uncinate fasciculus in proper noun naming: awake brain tumor resections and stereo EEG targeted electrical stimulation multiple case study

Jun Min Koay, Karen E. Blackmon, Erik H. Middlebrooks, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana, Anteneh M. Feyissa, Sanjeet S. Grewal, David S. Sabsevitz

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

While there is strong evidence from lesion and functional imaging studies implicating the left anterior temporal pole (LTP) in naming unique entities, less is known about white matter tracts in category-specific naming. We present evidence that implicates the uncinate fasciculus (UF) in proper noun naming. First, we describe two patients with left LTP gliomas who developed category specific worsening in proper noun naming in real time during awake surgery when the UF was surgically involved. We then describe a third case involving targeted electrical stimulation of the UF using stereo-electroencephalography (sEEG) that resulted in category specific naming disturbance for proper nouns.

Original languageEnglish
Pages (from-to)439-447
Number of pages9
JournalNeurocase
Volume28
Issue number5
DOIs
Publication statusPublished - 2022
Externally publishedYes

Keywords

  • Proper noun anomia
  • intraoperative neuropsychological testing
  • left temporal pole
  • stereo EEG
  • uncinate fasciculus

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