Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections

Tao Chen; Guang Chen; Guiqiang Wang; Sombat Treeprasertsuk; Cosmas Rinaldi Adithya Lesmana; Han Chieh Lin; Mamun Al-mahtab; Yogesh K. Chawla; Soek Siam Tan; Jia Horng Kao; Man Fung Yuen; Guan Huei Lee; Diana Alcantara-Payawal; Nobuaki Nakayama; Zaigham Abbas; Wasim Jafri; Dong Joon Kim; Ashok Choudhury; Rakhi Mahiwall; Jinlin Hou; Saeed Hamid; Jidong Jia; J. S. Bajaj; Fusheng Wang; Shiv K. Sarin; Qin Ning

doi:10.1007/s12072-023-10637-3

Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections

Tao Chen, Guang Chen, Guiqiang Wang, Sombat Treeprasertsuk, Cosmas Rinaldi Adithya Lesmana, Han Chieh Lin, Mamun Al-mahtab, Yogesh K. Chawla, Soek Siam Tan, Jia Horng Kao, Man Fung Yuen, Guan Huei Lee, Diana Alcantara-Payawal, Nobuaki Nakayama, Zaigham Abbas, Wasim Jafri, Dong Joon Kim, Ashok Choudhury, Rakhi Mahiwall, Jinlin HouSaeed Hamid, Jidong Jia, J. S. Bajaj, Fusheng Wang, Shiv K. Sarin, Qin Ning

Department of Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or progression of liver decompensation. Consequently, infections are among the most common complications of disease deterioration. There is an overwhelming need for standardized protocols for early diagnosis and appropriate management for patients with ESLD complicated by infections. Asia Pacific region has the largest number of ESLD patients, due to hepatitis B and the growing population of alcohol and NAFLD. Concomitant infections not only add to organ failure and high mortality but also to financial and healthcare burdens. This consensus document assembled up-to-date knowledge and experience from colleagues across the Asia–Pacific region, providing data on the principles as well as evidence-based current working protocols and practices for the diagnosis and treatment of patients with ESLD complicated by infections.

Original language	English
Journal	Hepatology International
DOIs	https://doi.org/10.1007/s12072-023-10637-3
Publication status	Accepted/In press - 2024

Keywords

ACLF
Acute decompensation
Antibiotics
Cirrhosis
Consensus
Decompensation
Infection
Organ failure
Sepsis
Septic shock
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12072-023-10637-3

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Chen, T., Chen, G., Wang, G., Treeprasertsuk, S., Lesmana, C. R. A., Lin, H. C., Al-mahtab, M., Chawla, Y. K., Tan, S. S., Kao, J. H., Yuen, M. F., Lee, G. H., Alcantara-Payawal, D., Nakayama, N., Abbas, Z., Jafri, W., Kim, D. J., Choudhury, A., Mahiwall, R., ... Ning, Q. (Accepted/In press). Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections. Hepatology International. https://doi.org/10.1007/s12072-023-10637-3

@article{e002721154044bbebb9e2a7047e6f848,

title = "Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections",

abstract = "End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or progression of liver decompensation. Consequently, infections are among the most common complications of disease deterioration. There is an overwhelming need for standardized protocols for early diagnosis and appropriate management for patients with ESLD complicated by infections. Asia Pacific region has the largest number of ESLD patients, due to hepatitis B and the growing population of alcohol and NAFLD. Concomitant infections not only add to organ failure and high mortality but also to financial and healthcare burdens. This consensus document assembled up-to-date knowledge and experience from colleagues across the Asia–Pacific region, providing data on the principles as well as evidence-based current working protocols and practices for the diagnosis and treatment of patients with ESLD complicated by infections.",

keywords = "ACLF, Acute decompensation, Antibiotics, Cirrhosis, Consensus, Decompensation, Infection, Organ failure, Sepsis, Septic shock, Treatment",

author = "Tao Chen and Guang Chen and Guiqiang Wang and Sombat Treeprasertsuk and Lesmana, {Cosmas Rinaldi Adithya} and Lin, {Han Chieh} and Mamun Al-mahtab and Chawla, {Yogesh K.} and Tan, {Soek Siam} and Kao, {Jia Horng} and Yuen, {Man Fung} and Lee, {Guan Huei} and Diana Alcantara-Payawal and Nobuaki Nakayama and Zaigham Abbas and Wasim Jafri and Kim, {Dong Joon} and Ashok Choudhury and Rakhi Mahiwall and Jinlin Hou and Saeed Hamid and Jidong Jia and Bajaj, {J. S.} and Fusheng Wang and Sarin, {Shiv K.} and Qin Ning",

note = "Publisher Copyright: {\textcopyright} Asian Pacific Association for the Study of the Liver 2024.",

year = "2024",

doi = "10.1007/s12072-023-10637-3",

language = "English",

journal = "Hepatology International",

issn = "1936-0533",

publisher = "Springer New York",

}

Chen, T, Chen, G, Wang, G, Treeprasertsuk, S, Lesmana, CRA, Lin, HC, Al-mahtab, M, Chawla, YK, Tan, SS, Kao, JH, Yuen, MF, Lee, GH, Alcantara-Payawal, D, Nakayama, N, Abbas, Z, Jafri, W, Kim, DJ, Choudhury, A, Mahiwall, R, Hou, J, Hamid, S, Jia, J, Bajaj, JS, Wang, F, Sarin, SK & Ning, Q 2024, 'Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections', Hepatology International. https://doi.org/10.1007/s12072-023-10637-3

TY - JOUR

T1 - Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections

AU - Chen, Tao

AU - Chen, Guang

AU - Wang, Guiqiang

AU - Treeprasertsuk, Sombat

AU - Lesmana, Cosmas Rinaldi Adithya

AU - Lin, Han Chieh

AU - Al-mahtab, Mamun

AU - Chawla, Yogesh K.

AU - Tan, Soek Siam

AU - Kao, Jia Horng

AU - Yuen, Man Fung

AU - Lee, Guan Huei

AU - Alcantara-Payawal, Diana

AU - Nakayama, Nobuaki

AU - Abbas, Zaigham

AU - Jafri, Wasim

AU - Kim, Dong Joon

AU - Choudhury, Ashok

AU - Mahiwall, Rakhi

AU - Hou, Jinlin

AU - Hamid, Saeed

AU - Jia, Jidong

AU - Bajaj, J. S.

AU - Wang, Fusheng

AU - Sarin, Shiv K.

AU - Ning, Qin

PY - 2024

Y1 - 2024

N2 - End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or progression of liver decompensation. Consequently, infections are among the most common complications of disease deterioration. There is an overwhelming need for standardized protocols for early diagnosis and appropriate management for patients with ESLD complicated by infections. Asia Pacific region has the largest number of ESLD patients, due to hepatitis B and the growing population of alcohol and NAFLD. Concomitant infections not only add to organ failure and high mortality but also to financial and healthcare burdens. This consensus document assembled up-to-date knowledge and experience from colleagues across the Asia–Pacific region, providing data on the principles as well as evidence-based current working protocols and practices for the diagnosis and treatment of patients with ESLD complicated by infections.

AB - End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or progression of liver decompensation. Consequently, infections are among the most common complications of disease deterioration. There is an overwhelming need for standardized protocols for early diagnosis and appropriate management for patients with ESLD complicated by infections. Asia Pacific region has the largest number of ESLD patients, due to hepatitis B and the growing population of alcohol and NAFLD. Concomitant infections not only add to organ failure and high mortality but also to financial and healthcare burdens. This consensus document assembled up-to-date knowledge and experience from colleagues across the Asia–Pacific region, providing data on the principles as well as evidence-based current working protocols and practices for the diagnosis and treatment of patients with ESLD complicated by infections.

KW - ACLF

KW - Acute decompensation

KW - Antibiotics

KW - Cirrhosis

KW - Consensus

KW - Decompensation

KW - Infection

KW - Organ failure

KW - Sepsis

KW - Septic shock

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85187116132&partnerID=8YFLogxK

U2 - 10.1007/s12072-023-10637-3

DO - 10.1007/s12072-023-10637-3

M3 - Article

AN - SCOPUS:85187116132

SN - 1936-0533

JO - Hepatology International

JF - Hepatology International

ER -

Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections

Abstract

Keywords

UN SDGs

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