TY - JOUR
T1 - Failure of short-course ceftriaxone chemotherapy for multidrug-resistant typhoid fever in children
T2 - A randomized controlled trial in Pakistan
AU - Bhutta, Zulfiqar A.
AU - Khan, Iqtidar A.
AU - Shadmani, Mamoon
PY - 2000/2
Y1 - 2000/2
N2 - The precise duration of therapy of multidrug-resistant (MDR) typhoid with broad-spectrum cephalosporins is uncertain. We prospectively randomized 57 children with culture-proven MDR typhoid to receive treatment with intravenous ceftriaxone (CRO) (65 mg/kg of body weight/day) for 7 days (short course; n = 29) or 14 days (conventional; n = 28). The response to therapy, as evaluated by the serial monitoring of the typhoid morbidity score and bacteriological clearance, was comparable between groups. In contrast to the conventional therapy, 14% of the children receiving CRO for 7 days had a confirmed bacteriological relapse within 4 weeks of stopping therapy.
AB - The precise duration of therapy of multidrug-resistant (MDR) typhoid with broad-spectrum cephalosporins is uncertain. We prospectively randomized 57 children with culture-proven MDR typhoid to receive treatment with intravenous ceftriaxone (CRO) (65 mg/kg of body weight/day) for 7 days (short course; n = 29) or 14 days (conventional; n = 28). The response to therapy, as evaluated by the serial monitoring of the typhoid morbidity score and bacteriological clearance, was comparable between groups. In contrast to the conventional therapy, 14% of the children receiving CRO for 7 days had a confirmed bacteriological relapse within 4 weeks of stopping therapy.
UR - http://www.scopus.com/inward/record.url?scp=0033968239&partnerID=8YFLogxK
U2 - 10.1128/AAC.44.2.450-452.2000
DO - 10.1128/AAC.44.2.450-452.2000
M3 - Article
C2 - 10639383
AN - SCOPUS:0033968239
SN - 0066-4804
VL - 44
SP - 450
EP - 452
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
