Familial clustering of stone disease

Jamsheer Jehangir Talati, Naveed Haroon

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


Across the world, from 15 to 68 % of patients with stone may have a family history of stone in their fi rst-degree relatives. A family history is associated with an earlier onset of disease and a greater chance of recurrence. The lifetime risk (to age 75) for a brother of the propositi is ~50 %. The reason for a high frequency of stone in the immediate family might be consanguinity, dietary, or environmental. If genetic factors are present, the inheritance appears polygenetic rather than monogenetic.

Original languageEnglish
Title of host publicationUrolithiasis
Subtitle of host publicationBasic Science and Clinical Practice
PublisherSpringer-Verlag London Ltd
Number of pages4
ISBN (Electronic)9781447143871
ISBN (Print)9781447143833
Publication statusPublished - 1 Jan 2012


  • Environmental
  • Family history
  • Lifetime risk
  • Monogenetic inheritance
  • Polygenetic inheritance
  • Urinary tract stone


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