Familial clustering of stone disease

Jamsheer Jehangir Talati; Naveed Haroon

doi:10.1007/978-1-4471-4387-1_17

Familial clustering of stone disease

Jamsheer Jehangir Talati, Naveed Haroon

Section of Urology, Department of Surgery, Medical College, Pakistan

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Across the world, from 15 to 68 % of patients with stone may have a family history of stone in their fi rst-degree relatives. A family history is associated with an earlier onset of disease and a greater chance of recurrence. The lifetime risk (to age 75) for a brother of the propositi is ~50 %. The reason for a high frequency of stone in the immediate family might be consanguinity, dietary, or environmental. If genetic factors are present, the inheritance appears polygenetic rather than monogenetic.

Original language	English
Title of host publication	Urolithiasis
Subtitle of host publication	Basic Science and Clinical Practice
Publisher	Springer-Verlag London Ltd
Pages	151-154
Number of pages	4
ISBN (Electronic)	9781447143871
ISBN (Print)	9781447143833
DOIs	https://doi.org/10.1007/978-1-4471-4387-1_17
Publication status	Published - 1 Jan 2012

Keywords

Environmental
Family history
Lifetime risk
Monogenetic inheritance
Polygenetic inheritance
Urinary tract stone

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10.1007/978-1-4471-4387-1_17

Cite this

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AB - Across the world, from 15 to 68 % of patients with stone may have a family history of stone in their fi rst-degree relatives. A family history is associated with an earlier onset of disease and a greater chance of recurrence. The lifetime risk (to age 75) for a brother of the propositi is ~50 %. The reason for a high frequency of stone in the immediate family might be consanguinity, dietary, or environmental. If genetic factors are present, the inheritance appears polygenetic rather than monogenetic.

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KW - Family history

KW - Lifetime risk

KW - Monogenetic inheritance

KW - Polygenetic inheritance

KW - Urinary tract stone

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BT - Urolithiasis

PB - Springer-Verlag London Ltd

ER -

Familial clustering of stone disease

Abstract

Keywords

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