Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients

Rohit Bakshi, R. S. Miletich, K. Henschel, Z. A. Shaikh, V. Janardhan, M. Wasay, L. M. Stengel, R. Ekes, P. R. Kinkel

Research output: Contribution to journalArticlepeer-review

171 Citations (Scopus)

Abstract

Fatigue is an unexplained but common and disabling symptom in MS. We assessed fatigue in 71 patients with MS and identified MS-fatigue (MSF) and MS-nonfatigue (MSNF) groups. Fatigue severity did not correlate with regional or global MRI plaque load or atrophy assessed by conventional sequences. No significant differences were noted in any MRI measures between MSF and MSNF groups. We suggest that brain MRI disease topography or severity does not explain fatigue in MS and that fatigue is likely due to mechanisms poorly characterized by conventional MRI.

Original languageEnglish
Pages (from-to)1151-1153
Number of pages3
JournalNeurology
Volume53
Issue number5
DOIs
Publication statusPublished - 22 Sept 1999

Keywords

  • Fatigue
  • MRI
  • MS

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