TY - JOUR
T1 - Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants
AU - Kosek, Margaret
AU - Haque, Rashidul
AU - Lima, Aldo
AU - Babji, Sudhir
AU - Shrestha, Sanjaya
AU - Qureshi, Shahida
AU - Amidou, Samie
AU - Mduma, Estomih
AU - Lee, Gwenyth
AU - Yori, Pablo Peñataro
AU - Guerrant, Richard L.
AU - Bhutta, Zulfiqar
AU - Mason, Carl
AU - Kang, Gagandeep
AU - Kabir, Mamun
AU - Amour, Caroline
AU - Bessong, Pascal
AU - Turab, Ali
AU - Seidman, Jessica
AU - Olortegui, Maribel Paredes
AU - Quetz, Josiane
AU - Lang, Dennis
AU - Gratz, Jean
AU - Miller, Mark
AU - Gottlieb, Michael
PY - 2013/2
Y1 - 2013/2
N2 - Enteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrheal illness in eight countries. Samples from 537 children contributed 1,169 AAT, 916 MPO, and 954 NEO test results that were significantly associated with linear growth. When combined to form a disease activity score, children with the highest score grew 1.08 cm less than children with the lowest score over the 6-month period following the tests after controlling for the incidence of diarrheal disease. This set of affordable non-invasive tests delineates those at risk of linear growth failure and may be used for the improved assessments of interventions to optimize growth during a critical period of early childhood.
AB - Enteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrheal illness in eight countries. Samples from 537 children contributed 1,169 AAT, 916 MPO, and 954 NEO test results that were significantly associated with linear growth. When combined to form a disease activity score, children with the highest score grew 1.08 cm less than children with the lowest score over the 6-month period following the tests after controlling for the incidence of diarrheal disease. This set of affordable non-invasive tests delineates those at risk of linear growth failure and may be used for the improved assessments of interventions to optimize growth during a critical period of early childhood.
UR - http://www.scopus.com/inward/record.url?scp=84874034697&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2012.12-0549
DO - 10.4269/ajtmh.2012.12-0549
M3 - Article
C2 - 23185075
AN - SCOPUS:84874034697
SN - 0002-9637
VL - 88
SP - 390
EP - 396
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 2
ER -
