Fibroadenoma with Pleomorphic Stromal Giant Cells: It's Not as Bad as It Looks!

Jonathan Wawire, Kamaljeet Singh, Margaret M. Steinhoff

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Clinically relevant histological categorization of fibroepithelial lesions can be a daunting task, especially in a core needle biopsy. Assessment of stromal nuclear atypia, including nuclear pleomorphism and mitotic activity, is a key morphological feature employed to classify fibroepithelial lesions. We describe a case of fibroadenoma with markedly atypical nuclear features in the stromal cells that led to misclassification as phyllodes tumor in the core needle biopsy. Excision showed a fibroadenoma containing pleomorphic stromal giant cells, with occasional mitotic figures, including atypical forms. Aforementioned nuclear findings in a fibroepithelial lesion raise a legitimate question of phyllodes tumor. Knowledge of this pitfall may help avoid overtreatment of an otherwise benign fibroepithelial lesion.

Original languageEnglish
Pages (from-to)425-427
Number of pages3
JournalInternational Journal of Surgical Pathology
Issue number5
Publication statusPublished - 1 Aug 2017


  • atypia
  • fibroadenoma
  • giant cells
  • mitosis
  • phyllodes
  • pleomorphic


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