Fish cholinesterases as biomarkers of sublethal effects of organophosphorus and carbamates in tissues of Labeo Rohita

Ghazala, Shahid Mahboob, L. Ahmad, S. Sultana, K. Alghanim, F. Al-Misned, Z. Ahmad

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Organophosphates and carbamates are major agrochemicals that strongly affect different neuroenzymes and the growth of various fish species. Here, we study the effect of sublethal concentrations of profenofos and carbofuran on the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) and the associated health risk in fish. Labeo rohita fingerlings were exposed to three sublethal concentrations of profenofos and carbofuran. The minimum cholinesterase activities in the brain, gills, muscle, kidney, liver, and blood were after exposure to profenofos (0.06 mg/L). The minimum AChE and BuChE activities in the brain, gills, muscle, kidney, liver, and blood were after exposure to carbofuran (0.28 and 0.198 mg/L). Exposure to both types of pesticides affected the functions of these organs, including metabolism and neurotransmission, to various extents at different exposure concentrations. These findings suggest that they are required to be properly monitored in the environment, to reduce their toxic effects on nontarget organisms.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalJournal of Biochemical and Molecular Toxicology
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

Keywords

  • Acetylcholine-sterase
  • Butyrylcholinesterase
  • Carbofuran
  • Inhibition
  • Profenofos

Fingerprint

Dive into the research topics of 'Fish cholinesterases as biomarkers of sublethal effects of organophosphorus and carbamates in tissues of Labeo Rohita'. Together they form a unique fingerprint.

Cite this