TY - JOUR
T1 - Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan
T2 - Data from community-based field clinics
AU - Rafiq, Yasraba
AU - Jabeen, Kauser
AU - Hasan, Rumina
AU - Jafri, Sana
AU - Laiq, Rabia
AU - Malik, Faisal
AU - Mangi, Rafique
AU - Channa, Abid
AU - Hasan, Zahra
PY - 2011/2
Y1 - 2011/2
N2 - A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.
AB - A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.
UR - http://www.scopus.com/inward/record.url?scp=78751680761&partnerID=8YFLogxK
U2 - 10.1128/AAC.00931-10
DO - 10.1128/AAC.00931-10
M3 - Article
C2 - 21135180
AN - SCOPUS:78751680761
SN - 0066-4804
VL - 55
SP - 929
EP - 930
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
