Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: Data from community-based field clinics

Yasraba Rafiq; Kauser Jabeen; Rumina Hasan; Sana Jafri; Rabia Laiq; Faisal Malik; Rafique Mangi; Abid Channa; Zahra Hasan

doi:10.1128/AAC.00931-10

Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: Data from community-based field clinics

Yasraba Rafiq, Kauser Jabeen, Rumina Hasan, Sana Jafri, Rabia Laiq, Faisal Malik, Rafique Mangi, Abid Channa, Zahra Hasan

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.

Original language	English (US)
Pages (from-to)	929-930
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	2
DOIs	https://doi.org/10.1128/AAC.00931-10
Publication status	Published - Feb 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/AAC.00931-10

Cite this

@article{b82533ac0e5f43fa866480a571b25efe,

title = "Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: Data from community-based field clinics",

abstract = "A fluoroquinolone (FQ) resistance rate of 5.9\% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1\% (5/45), and it was 4.9\% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.",

author = "Yasraba Rafiq and Kauser Jabeen and Rumina Hasan and Sana Jafri and Rabia Laiq and Faisal Malik and Rafique Mangi and Abid Channa and Zahra Hasan",

year = "2011",

month = feb,

doi = "10.1128/AAC.00931-10",

language = "English (US)",

volume = "55",

pages = "929--930",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan

T2 - Data from community-based field clinics

AU - Rafiq, Yasraba

AU - Jabeen, Kauser

AU - Hasan, Rumina

AU - Jafri, Sana

AU - Laiq, Rabia

AU - Malik, Faisal

AU - Mangi, Rafique

AU - Channa, Abid

AU - Hasan, Zahra

PY - 2011/2

Y1 - 2011/2

N2 - A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.

AB - A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.

UR - https://www.scopus.com/pages/publications/78751680761

U2 - 10.1128/AAC.00931-10

DO - 10.1128/AAC.00931-10

M3 - Article

C2 - 21135180

AN - SCOPUS:78751680761

SN - 0066-4804

VL - 55

SP - 929

EP - 930

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: Data from community-based field clinics

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this