TY - JOUR
T1 - Fluoroquinolone-resistant tuberculosis
T2 - Implications in settings with weak healthcare systems
AU - Jabeen, Kauser
AU - Shakoor, Sadia
AU - Hasan, Rumina
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015
Y1 - 2015
N2 - Fluoroquinolones (FQ) play an essential role in the treatment and control of multidrug-resistant tuberculosis (MDR-TB). They are also being evaluated as part of newer regimens under development for drug-sensitive TB. As newer FQ-based regimens are explored, knowledge of FQ resistance data from high TB burden countries becomes essential. We examine available FQ resistance data from high TB burden countries and demonstrate the need for comprehensive surveys to evaluate FQ resistance in these countries. The factors driving FQ resistance in such conditions and the cost of such resistance to weak healthcare systems are discussed. The need for a comprehensive policy for addressing the issue of FQ resistance is highlighted.
AB - Fluoroquinolones (FQ) play an essential role in the treatment and control of multidrug-resistant tuberculosis (MDR-TB). They are also being evaluated as part of newer regimens under development for drug-sensitive TB. As newer FQ-based regimens are explored, knowledge of FQ resistance data from high TB burden countries becomes essential. We examine available FQ resistance data from high TB burden countries and demonstrate the need for comprehensive surveys to evaluate FQ resistance in these countries. The factors driving FQ resistance in such conditions and the cost of such resistance to weak healthcare systems are discussed. The need for a comprehensive policy for addressing the issue of FQ resistance is highlighted.
KW - Drug-resistant tuberculosis
KW - Fluoroquinolone resistance
KW - Health systems
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85001575056&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2015.01.006
DO - 10.1016/j.ijid.2015.01.006
M3 - Article
C2 - 25809767
AN - SCOPUS:85001575056
SN - 1201-9712
VL - 32
SP - 118
EP - 123
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
