TY - JOUR
T1 - Follicular sensitivity index
T2 - A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection
AU - Rehman, Rehana
AU - Zafar, Amara
AU - Zahid, Nida
AU - Mohammed, Nuruddin
N1 - Publisher Copyright:
© 2020 College of Physicians and Surgeons Pakistan. All rights reserved.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76% specificity, sensitivity of 86% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.
AB - Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76% specificity, sensitivity of 86% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.
KW - Follicular output rate
KW - Follicular sensitivity index
KW - Infertility
KW - Intra-cytoplasmic sperm injection
KW - Ovarian response
UR - http://www.scopus.com/inward/record.url?scp=85086226943&partnerID=8YFLogxK
U2 - 10.29271/jcpsp.2020.4.443
DO - 10.29271/jcpsp.2020.4.443
M3 - Article
C2 - 32513372
AN - SCOPUS:85086226943
SN - 1022-386X
VL - 30
SP - 443
EP - 445
JO - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
IS - 4
ER -