Follicular sensitivity index: A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection

Rehana Rehman, Amara Zafar, Nida Zahid, Nuruddin Mohammed

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76% specificity, sensitivity of 86% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.

Original languageEnglish
Pages (from-to)443-445
Number of pages3
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Apr 2020

Keywords

  • Follicular output rate
  • Follicular sensitivity index
  • Infertility
  • Intra-cytoplasmic sperm injection
  • Ovarian response

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