Follicular sensitivity index: A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection

Rehana Rehman; Amara Zafar; Nida Zahid; Nuruddin Mohammed

doi:10.29271/jcpsp.2020.4.443

Follicular sensitivity index: A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection

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1 Citation (Scopus)

Abstract

Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76% specificity, sensitivity of 86% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.

Original language	English (UK)
Pages (from-to)	443-445
Number of pages	3
Journal	Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Volume	30
Issue number	4
DOIs	https://doi.org/10.29271/jcpsp.2020.4.443
Publication status	Published - 1 Apr 2020

Keywords

Follicular output rate
Follicular sensitivity index
Infertility
Intra-cytoplasmic sperm injection
Ovarian response

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10.29271/jcpsp.2020.4.443

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title = "Follicular sensitivity index: A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection",

abstract = "Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76\% specificity, sensitivity of 86\% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.",

keywords = "Follicular output rate, Follicular sensitivity index, Infertility, Intra-cytoplasmic sperm injection, Ovarian response",

author = "Rehana Rehman and Amara Zafar and Nida Zahid and Nuruddin Mohammed",

year = "2020",

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doi = "10.29271/jcpsp.2020.4.443",

language = "English (UK)",

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pages = "443--445",

journal = "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP",

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T1 - Follicular sensitivity index

T2 - A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection

AU - Rehman, Rehana

AU - Zafar, Amara

AU - Zahid, Nida

AU - Mohammed, Nuruddin

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76% specificity, sensitivity of 86% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.

AB - Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytoplasmic sperm injection (ICSI). In a retrospective study, FSI of 1,385 females was calculated as [pre-ovulatory follicle count (PFC) × 100,000]/ [antral follicle count (AFC) × total received stimulation doses]. Females were then categorised into low, middle and high FSI groups according to FSI tertile values. FSI was 8.65 ±2.82 in non-pregnant as compared to 12.02 ±2.04 (p <0.01) in pregnant cohort. FSI turned out to be a strong predictor of successful conception on the receiver operating curve with cutoff value 10.36 at 76% specificity, sensitivity of 86% and area under the curve (AUC; 0.83). Calculation of FSI can thus predict the chances of successful conception in females with different causes of infertility.

KW - Follicular output rate

KW - Follicular sensitivity index

KW - Infertility

KW - Intra-cytoplasmic sperm injection

KW - Ovarian response

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DO - 10.29271/jcpsp.2020.4.443

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IS - 4

ER -

Follicular sensitivity index: A Tool to Predict Successful Conception after Intra-cytoplasmic Sperm Injection

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