Follicular sensitivity index and insulin growth factor-1: Predictor of success after intracytoplasmic sperm injection

Rehana Rehman, Huma Salahuddin, Amara Zafar, Sadia Rehman, Nargis Anjum, Zara Sami

Research output: Contribution to journalArticlepeer-review


To compare follicular sensitivity index (FSI) and Insulin Growth Factor (IGF) -1 for prediction of oocyte yield, embryo quality and the pregnancy consequence in infertile females booked for Intracytoplasmic Sperm Injection (ICSI). Study design was cross sectional where in 133 infertile females enrolled for ICSI were included. Antral follicle count (AFC), Pre-ovulatory follicle count (PFC), FSI, total dosages of follicle stimulating hormone (FSH); designed as pre-ovulatory follicle count × 100,000/ (antral follicle count × total administered stimulation doses) were estimated. IGF was measured by Enzyme Linked Immuno Sorbent Assay. Efficacious pregnancy conception after Intracytoplasmic Sperm Injection (ICSI) was established by means of intrauterine gestational sac with cardiac activity after transfer of embryo. Odds ratio was determined for clinical pregnancy by means of FSI and IGF-I, p-values ≤0.05 were considered significant. FSI was found to be a stronger predictor of pregnancy than IGF-I. Both IGF-I and FSI contributed positive association with clinical pregnancy consequences but FSI was found to be a more reliable predictor of clinical pregnancy. The advantage of using FSI over IGF-I is that FSI is a noninvasive test while IGF-I needs blood sampling. We recommend calculation of FSI for prediction of pregnancy outcomes.

Original languageEnglish
Pages (from-to)1761-1765
Number of pages5
JournalPakistan Journal of Pharmaceutical Sciences
Issue number6
Publication statusPublished - Nov 2022
Externally publishedYes


  • Follicular sensitivity index
  • infertility
  • insulin growth factor-1
  • intracytoplasmic sperm injection


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