Formulation of a freeze-dried kit for 188Re-MAG3 and its quality control

S. Pervez; A. Mushtaq; M. Arif

doi:10.1023/A:1024764703623

Formulation of a freeze-dried kit for ¹⁸⁸Re-MAG₃ and its quality control

S. Pervez, A. Mushtaq, M. Arif

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The synthesis of ¹⁸⁸Re-MAG₃ is described using ¹⁸⁸Re, which was obtained from the alumina based ¹⁸⁸W/¹⁸⁸Re generator. Dependence of the radiolabeling yields of ¹⁸⁸Re-MAG₃ on reducing agent concentration, Bz-MAG₃ concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of ¹⁸⁸Re-MAG₃ was 98%. TLC and HPLC techniques were employed to monitor the different species formed Biodistribution study of ¹⁸⁸Re-MAG₃ was carried out in rats and compared with behavior of ^99mTC-MAG₃.

Original language	English
Pages (from-to)	421-424
Number of pages	4
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	257
Issue number	2
DOIs	https://doi.org/10.1023/A:1024764703623
Publication status	Published - 1 Aug 2003
Externally published	Yes

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abstract = "The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTC-MAG3.",

author = "S. Pervez and A. Mushtaq and M. Arif",

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AU - Pervez, S.

AU - Mushtaq, A.

AU - Arif, M.

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N2 - The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTC-MAG3.

AB - The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTC-MAG3.

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JF - Journal of Radioanalytical and Nuclear Chemistry

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ER -

Formulation of a freeze-dried kit for ¹⁸⁸Re-MAG₃ and its quality control

Abstract

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