Formulation of a freeze-dried kit for the preparation of 99mTc-tetrofosmin

S. Pervez, A. Mushtaq

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6 Citations (Scopus)


A new formulation of a freeze-dried kit for the labeling of tetrofosmin with technetium-99m has been developed. The kit contains lyophilized mixture of 0.320 mg tetrofosmin [6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9- diphosphatetradecane], 0.025 mg stannous chloride dihydrate, 5 mg sodium tartrate and 5 mg sodium hydrogen carbonate. The product contains no antimicrobial preservative. When 99mTc pertechnetate up to 6 mL saline containing 200 mCi is added to lyophilized mixture, a lipophilic, cationic 99mTc complex is formed, 99mTc-tetrofosmin. The performance of newly developed kit is compared with commercially available MYOVIEW kit for heart imaging. The patient studies show that the images of heart obtained by 99mTc-tetrofosmin prepared by new formulation are equally good to MYOVIEW.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number3
Publication statusPublished - Sept 2009
Externally publishedYes


  • Heart imaging
  • Tc-tetrofosmin
  • Transchelating agent tartrate


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