Fractional mathematical modeling of malaria disease with treatment & insecticides

Muhammad Sinan, Hijaz Ahmad, Zubair Ahmad, Jamel Baili, Saqib Murtaza, M. A. Aiyashi, Thongchai Botmart

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Many fatal diseases spread through vertical transmission while some of them spread through horizontal transmission and others transmit through both modes of transmission. Horizontal transmission illnesses are usually carried by a vector, which might be an animal, a bird, or an insect. Plasmodium parasites that dwell in red blood cells produce malaria, an infectious illness. This parasite is mostly transmitted to humans via mosquitoes. The dynamics of Malaria illness among human persons and vectors are examined in this study. The impact of the vector (mosquito) on disease transmission is also taken into account. The problem is described using nonlinear ODEs that are then generalized using the Atangana–Baleanu fractional derivative. Some theoretical analyses such as existence and uniqueness and stability via Ulam–Hyres stability analysis and optimal control strategies have been done. The numerical solution has been achieved via a numerical technique by implementing MATLAB software. Results of fractional, as well as classical order, are portrayed through different graphs while some figures are displayed for the global asymptotical stability of the model. From the graphical results, it can be noticed that the control parameters drastically decrease the number of infected human and vector population which will off course minimize the spread of infection among the human population. In addition to that, from the graphical results, it also be noticed that our model is globally asymptomatically stable as the solution converges to its equilibrium. Moreover, the use of bednets and insecticides can reduce the spread of infection dramatically while the impact of medication and treatment on the control of infection is comparatively less.

Original languageEnglish
Article number105220
JournalResults in Physics
Publication statusPublished - Mar 2022
Externally publishedYes


  • Atangana baleanu operator
  • Existence and uniqueness
  • Mathematical modeling
  • Mittag-Leffler function
  • Optimal control strategies
  • Ulam stability analysis


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