Fragile X gene expansions are not associated with dementia

Deborah A. Hall; David A. Bennett; Christopher M. Filley; Raj C. Shah; Benzi Kluger; Bichun Ouyang; Elizabeth Berry-Kravis

doi:10.1016/j.neurobiolaging.2014.04.027

Fragile X gene expansions are not associated with dementia

Deborah A. Hall, David A. Bennett, Christopher M. Filley, Raj C. Shah, Benzi Kluger, Bichun Ouyang, Elizabeth Berry-Kravis

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The purpose of this study was to determine the frequency of fragile X mental retardation 1 (. FMR1) premutation size expansions in individuals with Alzheimer's disease (AD) and other cognitive disorders compared with control subjects. FMR1 genetic screening was completed in patients being seen in a neurobehavioral or AD clinics. Appropriate controls were also collected. A second cohort was a community based, autopsy confirmed, sample of individuals with normal cognitive function, mild cognitive impairment, or AD. There was not an increased frequency of FMR1 expansions in individuals with cognitive disorders, including AD, compared with control subjects.

Original language	English (US)
Pages (from-to)	2637-2638
Number of pages	2
Journal	Neurobiology of Aging
Volume	35
Issue number	11
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.04.027
Publication status	Published - 1 Nov 2014
Externally published	Yes

Keywords

Alzheimer's disease
FMR1
Fragile X

Access to Document

10.1016/j.neurobiolaging.2014.04.027

Cite this

@article{dda173bac76647fc93f195c20bb14d86,

title = "Fragile X gene expansions are not associated with dementia",

abstract = "The purpose of this study was to determine the frequency of fragile X mental retardation 1 (. FMR1) premutation size expansions in individuals with Alzheimer's disease (AD) and other cognitive disorders compared with control subjects. FMR1 genetic screening was completed in patients being seen in a neurobehavioral or AD clinics. Appropriate controls were also collected. A second cohort was a community based, autopsy confirmed, sample of individuals with normal cognitive function, mild cognitive impairment, or AD. There was not an increased frequency of FMR1 expansions in individuals with cognitive disorders, including AD, compared with control subjects.",

keywords = "Alzheimer's disease, FMR1, Fragile X",

author = "Hall, \{Deborah A.\} and Bennett, \{David A.\} and Filley, \{Christopher M.\} and Shah, \{Raj C.\} and Benzi Kluger and Bichun Ouyang and Elizabeth Berry-Kravis",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = nov,

day = "1",

doi = "10.1016/j.neurobiolaging.2014.04.027",

language = "English (US)",

volume = "35",

pages = "2637--2638",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Fragile X gene expansions are not associated with dementia

AU - Hall, Deborah A.

AU - Bennett, David A.

AU - Filley, Christopher M.

AU - Shah, Raj C.

AU - Kluger, Benzi

AU - Ouyang, Bichun

AU - Berry-Kravis, Elizabeth

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The purpose of this study was to determine the frequency of fragile X mental retardation 1 (. FMR1) premutation size expansions in individuals with Alzheimer's disease (AD) and other cognitive disorders compared with control subjects. FMR1 genetic screening was completed in patients being seen in a neurobehavioral or AD clinics. Appropriate controls were also collected. A second cohort was a community based, autopsy confirmed, sample of individuals with normal cognitive function, mild cognitive impairment, or AD. There was not an increased frequency of FMR1 expansions in individuals with cognitive disorders, including AD, compared with control subjects.

AB - The purpose of this study was to determine the frequency of fragile X mental retardation 1 (. FMR1) premutation size expansions in individuals with Alzheimer's disease (AD) and other cognitive disorders compared with control subjects. FMR1 genetic screening was completed in patients being seen in a neurobehavioral or AD clinics. Appropriate controls were also collected. A second cohort was a community based, autopsy confirmed, sample of individuals with normal cognitive function, mild cognitive impairment, or AD. There was not an increased frequency of FMR1 expansions in individuals with cognitive disorders, including AD, compared with control subjects.

KW - Alzheimer's disease

KW - FMR1

KW - Fragile X

UR - https://www.scopus.com/pages/publications/84917699896

U2 - 10.1016/j.neurobiolaging.2014.04.027

DO - 10.1016/j.neurobiolaging.2014.04.027

M3 - Article

C2 - 24958193

AN - SCOPUS:84917699896

SN - 0197-4580

VL - 35

SP - 2637

EP - 2638

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 11

ER -

Fragile X gene expansions are not associated with dementia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this