Frequency of IDH1 mutation in adult-type diffuse astrocytic gliomas in a tertiary hospital in Kenya

Samuel Gakinya, Anderson Mutuiri, Timothy Onyuma, Beverly Cheserem, Edwin Mogere

Research output: Contribution to journalArticlepeer-review

Abstract

The 2021 WHO classification of gliomas has separated gliomas based on their IDH mutation status, reflecting differences in their pathogenesis and clinical characteristics. There is a paucity of data on the prevalence of IDH mutations in gliomas in this region. This study aimed to determine the frequency of the IDH1 mutation in adult-type diffuse astrocytic gliomas in a tertiary hospital in Kenya. Approximately half of the gliomas were positive for the IDH1 mutation, with a slight male predominance. Our study provides crucial insights into the frequency of IDH1 mutations in gliomas in Kenya.

Original languageEnglish
Article number1305714
JournalFrontiers in Medicine
Volume11
DOIs
Publication statusPublished - 2024

Keywords

  • Africa
  • astrocytoma
  • frequency
  • glioma
  • IDH1
  • Kenya

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