Fungal osteomyelitis in a patient with chronic granulomatous disease: Case report and review of the literature

Muhammad Khalid, Syed Asad Ali

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Chronic granulomatous disease (CGD) is the most common of the primary immunodeficiency in children. It is caused by single gene defect resulting in dysfunctional nicotinamide adenine dineucleotide phosphate (NADPH) oxidase complex causing recurrent bacterial and fungal infections. Here we present the case of a 9 year old boy who was a known case of CGD since three years of age. He presented with recent history of fever, left sided pain in the scapular region and difficulty in breathing. Chest imaging revealed developing left upper lobe consolidation and erosion of the 3rd posterior rib. The child underwent video assisted thoracoscopic surgery (VATS) and biopsy of the lesion. Histopathology revealed fungal hyphae which were confirmed to be Aspergillus nidulans on staining. He was successfully treated with voriconazole therapy. We will also review the literature on fungal osteomyelitis in CGD patients.

Original languageEnglish
Pages (from-to)1387-1390
Number of pages4
JournalJournal of the Pakistan Medical Association
Volume68
Issue number9
Publication statusPublished - Sept 2018

Keywords

  • Aspergillus nidulans
  • Chronic granulomatous disease
  • Osteomyelitis
  • Primary immunodeficiency

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