Fuzzy control of baseline activity within the basal ganglia of rat brain

M. Z. Ozair, S. Enam-Ur-Rehman, S. A. Enam

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Deep brain stimulation (DBS) is an increasingly popular treatment modality for Parkinson's disease (PD) based on chronic electrical stimulation of the basal ganglia. The basal ganglia are responsible for regulating motor control of the human body, a function exemplified by disease states such as PD. We describe a novel technique based on a chronically implantable neural prosthetic device that could be used as a potential treatment in many basal ganglia disorders, including PD. The prosthetic device implements a fuzzy control of the baseline excitation of the motor cortex and derives a feedback loop from the thalamocortical pathway, thus forming a closed loop control. It improves over DBS by being self-adjustable, thereby eradicating the need of repeated adjustments of various parameters of the excitatory signal(s). The neural prosthetic device can be implanted in a rat brain and the fuzzy control rule set be derived from in vitro organotypic slice culture models of the basal ganglia.

Original languageEnglish
Title of host publicationProceedings - INMIC 2003
Subtitle of host publicationIEEE 7th International Multi Topic Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages3
ISBN (Electronic)0780381831, 9780780381834
Publication statusPublished - 2003
Externally publishedYes
Event7th IEEE International Multi Topic Conference, INMIC 2003 - Islamabad, Pakistan
Duration: 8 Dec 20039 Dec 2003

Publication series

NameProceedings - INMIC 2003: IEEE 7th International Multi Topic Conference


Conference7th IEEE International Multi Topic Conference, INMIC 2003


  • Basal ganglia
  • Brain stimulation
  • Electrical stimulation
  • Fuzzy control
  • Humans
  • Motor drives
  • Neural prosthesis
  • Parkinson's disease
  • Prosthetics
  • Satellite broadcasting


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